Multicenter patch testing with a resol resin based on phenol and formaldehyde within the international contact dermatitis research group

Marléne Isaksson, Iris Ale, Klaus Andersen, Thomas Diepgen, Peter Elsner, An Goossens, Chee Leok Goh, Hemangi Jerajani, Howard Maibach, Kayoko Matsunaga, John McFadden, Rosemary Nixon, Denis Sasseville, Magnus Bruze

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin included in most baseline patch test series. Objective The aims of this study were to investigate the contact allergy rate to PFR-2 in an international population and to investigate associated simultaneous allergic reactions. Methods Thirteen centers representing the International Contact Dermatitis Research Group included PFR-2 into their patch test baseline series during a period of 6 months in 2012. Results Of 2259 patients tested, 28 (1.2%) reacted to PFR-2. Of those 28 individuals, one had a positive reaction to formaldehyde and 2 to p-tertiary-butylphenol-formaldehyde resin. Simultaneous allergic reactions were noted to colophonium in 3, to Myroxylon pereirae in 5, and to fragrance mix I in 8. Conclusions The contact allergy frequency in the tested population (1.2%) merits its inclusion into the international baseline series and possibly also into other baseline series after appropriate investigations. Significantly, overrepresented simultaneous allergic reactions were noted for M. pereirae and fragrance mix I.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalDermatitis
Volume26
Issue number5
DOIs
Publication statusPublished - 24-09-2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

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