Multicenter prospective in vivo study of an endocytoscope system (ECS) for superficial esophageal cancer

Shuko Morita, Kenichi Goda, Tomonori Yano, Mitsuru Kaise, Mototsugu Kato, Haruhiro Inoue, Yasumasa Niwa, Shinya Kodashima, Ryoji Miyahara, Atsushi Ochiai, Masahiro Ikegami, Shigeharu Hamatani, Tadakazu Shimoda, Yasuo Ohkura, Junko Aida, Yukihiro Nakanishi, Kenichi Yoshimura, Hideki Ishikawa, Kaiyo Takubo, Manabu Muto

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1 Citation (Scopus)


Background: Endocytoscope systems (ECS) can visualize cellular nuclei of the mucosa of the gastrointestinal tract and are predicted to provide real-time microscopic diagnosis. However, their practical diagnostic performance remains unclear. Therefore, we conducted a multicenter prospective study to evaluate the visualization of superficial esophageal neoplasm in vivo using an ECS, and its diagnostic capability. Methods: The study target was histologically confirmed squamous cell carcinoma (SCC) and high-grade intraepithelial neoplasia (HGIN). An integrated ECS was used to obtain ECS images. In each patient, three ECS images of cancerous and corresponding noncancerous regions were selected for evaluation. A pathological review board of five certified pathologists made the final diagnosis of the images. The primary endpoint was the sensitivity of ECS diagnosis by pathologists. Results: ECS images of 68 patients were assessed: 42 lesions were mucosal SCC, 13 were submucosal SCC, and 13 were HGIN. The rate of assessable images was 96% (95% CI 87.6–99.1). The sensitivity of ECS diagnosis by pathologists was 88% (95% CI 77.2–94.5). Conclusions: ECS can provide high-quality images of cancerous lesions and a high diagnostic accuracy by pathologists, and could be useful for real-time endoscopic histological diagnosis of SCC and HGIN. Trial registration: The UMIN Clinical Trials Registry Identification Number: 000004218.

Original languageEnglish
Pages (from-to)808-813
Number of pages6
JournalJournal of Gastroenterology
Issue number9
Publication statusPublished - 09-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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