Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil

Doroti De Oliveira Garcia, Yohei Doi, Dora Szabo, Jennifer M. Adams-Haduch, Tânia M.I. Vaz, Daniela Leite, Maria Clara Padoveze, Maristela P. Freire, Fernanda P. Silveira, David L. Paterson

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Abstract

An outbreak of cephalosporin-resistant Klebsiella pneumoniae occurred in a neonatal intensive care unit in São Paulo, Brazil. Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. blaCTX-M-2/59 genes were located on closely related plasmids that were transferable.

Original languageEnglish
Pages (from-to)1790-1793
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number5
DOIs
Publication statusPublished - 01-05-2008
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Garcia, D. D. O., Doi, Y., Szabo, D., Adams-Haduch, J. M., Vaz, T. M. I., Leite, D., Padoveze, M. C., Freire, M. P., Silveira, F. P., & Paterson, D. L. (2008). Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. Antimicrobial agents and chemotherapy, 52(5), 1790-1793. https://doi.org/10.1128/AAC.01440-07