Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil

Doroti De Oliveira Garcia, Yohei Doi, Dora Szabo, Jennifer M. Adams-Haduch, Tânia M.I. Vaz, Daniela Leite, Maria Clara Padoveze, Maristela P. Freire, Fernanda P. Silveira, David L. Paterson

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

An outbreak of cephalosporin-resistant Klebsiella pneumoniae occurred in a neonatal intensive care unit in São Paulo, Brazil. Of the 10 pulsotypes identified during the outbreak and follow-up periods, nine produced CTX-M-2 or its new variant CTX-M-59 and one produced SHV-5. blaCTX-M-2/59 genes were located on closely related plasmids that were transferable.

Original languageEnglish
Pages (from-to)1790-1793
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number5
DOIs
Publication statusPublished - 01-05-2008

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Neonatal Intensive Care Units
Klebsiella pneumoniae
Disease Outbreaks
Brazil
Cephalosporins
Plasmids
Genes
beta-lactamase CTX-2

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Garcia, Doroti De Oliveira ; Doi, Yohei ; Szabo, Dora ; Adams-Haduch, Jennifer M. ; Vaz, Tânia M.I. ; Leite, Daniela ; Padoveze, Maria Clara ; Freire, Maristela P. ; Silveira, Fernanda P. ; Paterson, David L. / Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. In: Antimicrobial agents and chemotherapy. 2008 ; Vol. 52, No. 5. pp. 1790-1793.
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Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. / Garcia, Doroti De Oliveira; Doi, Yohei; Szabo, Dora; Adams-Haduch, Jennifer M.; Vaz, Tânia M.I.; Leite, Daniela; Padoveze, Maria Clara; Freire, Maristela P.; Silveira, Fernanda P.; Paterson, David L.

In: Antimicrobial agents and chemotherapy, Vol. 52, No. 5, 01.05.2008, p. 1790-1793.

Research output: Contribution to journalArticle

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