TY - JOUR
T1 - Multidetector Computed Tomography Myocardial Perfusion Imaging During Adenosine Stress
AU - George, Richard T.
AU - Silva, Caterina
AU - Cordeiro, Marco A.S.
AU - DiPaula, Anthony
AU - Thompson, Douglas R.
AU - McCarthy, William F.
AU - Ichihara, Takashi
AU - Lima, Joao A.C.
AU - Lardo, Albert C.
N1 - Funding Information:
Dr. Ichihara is an employee of Toshiba American Medical Systems, Inc. Drs. Lardo and Lima are, in part, funded by a research grant from Toshiba American Medical Systems, Inc. The terms of this arrangement are being managed by Johns Hopkins University in accordance with its conflict of interest policies. Research support: Donald W. Reynolds Foundation, Las Vegas, Nevada; Toshiba American Medical Systems, Tufton, California. Markus Schwaiger, MD, acted as Guest Editor for this paper.
PY - 2006/7/4
Y1 - 2006/7/4
N2 - Objectives: The purpose of this study is to validate the accuracy of multidetector computed tomography (MDCT) to measure differences in regional myocardial perfusion during adenosine stress in a canine model of left anterior descending (LAD) artery stenosis, during first-pass, contrast-enhanced helical MDCT. Background: Myocardial perfusion imaging by MDCT may have significant implications in the diagnosis and treatment of coronary artery disease. Methods: Eight dogs were prepared with a LAD stenosis, and contrast-enhanced MDCT imaging was performed 5 min into adenosine infusion (0.14 to 0.21 mg/kg/min). Images were analyzed using a semiautomated approach to define the regional signal density (SD) ratio (myocardial SD/left ventricular blood pool SD) in stenosed and remote territories, and then compared with microsphere myocardial blood flow (MBF) measurements. Results: Mean MBF in stenosed versus remote territories was 1.37 ± 0.46 ml/g/min and 1.29 ± 0.48 ml/g/min at baseline (p = NS) and 2.54 ± 0.93 ml/g/min and 8.94 ± 5.74 ml/g/min during adenosine infusion, respectively (p < 0.05). Myocardial SD was 92.3 ± 39.5 HU in stenosed versus 180.4 ± 41.9 HU in remote territories (p < 0.001). There was a significant linear association of the SD ratio with MBF in the stenosed territory (R = 0.98, p = 0.001) and between regional myocardial SD ratio and MBF <8 ml/g/min, slope = 0.035, SE = 0.007, p < 0.0001. Overall, there was a significant non-linear relationship over the range of flows studied (LR chi-square [2 degrees of freedom] = 31.8, p < 0.0001). Conclusions: Adenosine-augmented MDCT myocardial perfusion imaging provides semiquantitative measurements of myocardial perfusion during first-pass MDCT imaging in a canine model of LAD stenosis.
AB - Objectives: The purpose of this study is to validate the accuracy of multidetector computed tomography (MDCT) to measure differences in regional myocardial perfusion during adenosine stress in a canine model of left anterior descending (LAD) artery stenosis, during first-pass, contrast-enhanced helical MDCT. Background: Myocardial perfusion imaging by MDCT may have significant implications in the diagnosis and treatment of coronary artery disease. Methods: Eight dogs were prepared with a LAD stenosis, and contrast-enhanced MDCT imaging was performed 5 min into adenosine infusion (0.14 to 0.21 mg/kg/min). Images were analyzed using a semiautomated approach to define the regional signal density (SD) ratio (myocardial SD/left ventricular blood pool SD) in stenosed and remote territories, and then compared with microsphere myocardial blood flow (MBF) measurements. Results: Mean MBF in stenosed versus remote territories was 1.37 ± 0.46 ml/g/min and 1.29 ± 0.48 ml/g/min at baseline (p = NS) and 2.54 ± 0.93 ml/g/min and 8.94 ± 5.74 ml/g/min during adenosine infusion, respectively (p < 0.05). Myocardial SD was 92.3 ± 39.5 HU in stenosed versus 180.4 ± 41.9 HU in remote territories (p < 0.001). There was a significant linear association of the SD ratio with MBF in the stenosed territory (R = 0.98, p = 0.001) and between regional myocardial SD ratio and MBF <8 ml/g/min, slope = 0.035, SE = 0.007, p < 0.0001. Overall, there was a significant non-linear relationship over the range of flows studied (LR chi-square [2 degrees of freedom] = 31.8, p < 0.0001). Conclusions: Adenosine-augmented MDCT myocardial perfusion imaging provides semiquantitative measurements of myocardial perfusion during first-pass MDCT imaging in a canine model of LAD stenosis.
UR - https://www.scopus.com/pages/publications/33646060010
UR - https://www.scopus.com/pages/publications/33646060010#tab=citedBy
U2 - 10.1016/j.jacc.2006.04.014
DO - 10.1016/j.jacc.2006.04.014
M3 - Article
C2 - 16814661
AN - SCOPUS:33646060010
SN - 0735-1097
VL - 48
SP - 153
EP - 160
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 1
ER -