TY - JOUR
T1 - Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water
AU - Kato, Masashi
AU - Ohgami, Nobutaka
AU - Ohnuma, Shoko
AU - Hashimoto, Kazunori
AU - Tazaki, Akira
AU - Xu, Huadong
AU - Kondo-Ida, Lisa
AU - Yuan, Tian
AU - Tsuchiyama, Tomoyuki
AU - He, Tingchao
AU - Kurniasari, Fitri
AU - Gu, Yishuo
AU - Chen, Wei
AU - Deng, Yuqi
AU - Komuro, Kanako
AU - Tong, Keming
AU - Yajima, Ichiro
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/5/27
Y1 - 2020/5/27
N2 - Well water could be a stable source of drinking water. Recently, the use of well water as drinking water has been encouraged in developing countries. However, many kinds of disorders caused by toxic elements in well drinking water have been reported. It is our urgent task to resolve the global issue of element-originating diseases. In this review article, our multidisciplinary approaches focusing on oncogenic toxicities and disturbances of sensory organs (skin and ear) induced by arsenic and barium are introduced. First, our environmental monitoring in developing countries in Asia showed elevated concentrations of arsenic and barium in well drinking water. Then our experimental studies in mice and our epidemiological studies in humans showed arsenic-mediated increased risks of hyperpigmented skin and hearing loss with partial elucidation of their mechanisms. Our experimental studies using cultured cells with focus on the expression and activity levels of intracellular signal transduction molecules such as c-SRC, c-RET, and oncogenic RET showed risks for malignant transformation and/or progression arose from arsenic and barium. Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.
AB - Well water could be a stable source of drinking water. Recently, the use of well water as drinking water has been encouraged in developing countries. However, many kinds of disorders caused by toxic elements in well drinking water have been reported. It is our urgent task to resolve the global issue of element-originating diseases. In this review article, our multidisciplinary approaches focusing on oncogenic toxicities and disturbances of sensory organs (skin and ear) induced by arsenic and barium are introduced. First, our environmental monitoring in developing countries in Asia showed elevated concentrations of arsenic and barium in well drinking water. Then our experimental studies in mice and our epidemiological studies in humans showed arsenic-mediated increased risks of hyperpigmented skin and hearing loss with partial elucidation of their mechanisms. Our experimental studies using cultured cells with focus on the expression and activity levels of intracellular signal transduction molecules such as c-SRC, c-RET, and oncogenic RET showed risks for malignant transformation and/or progression arose from arsenic and barium. Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.
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U2 - 10.1186/s12199-020-00855-8
DO - 10.1186/s12199-020-00855-8
M3 - Review article
C2 - 32460744
AN - SCOPUS:85085538448
SN - 1342-078X
VL - 25
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine
IS - 1
M1 - 02000855
ER -
