TY - JOUR
T1 - Multifunctional Roles of Activins in the Brain
AU - Ageta, Hiroshi
AU - Tsuchida, Kunihiro
N1 - Funding Information:
We acknowledge the collaborative studies with Dr. K. Inokuchi at Toyama University/MITILS. This work was partly supported by a research grant (H20-018) on psychiatric and neurological diseases from the Ministry of Health, Labour and Welfare and an intramural research grant (20B-13) for neurological and psychiatric disorders of NCNP.
PY - 2011
Y1 - 2011
N2 - Activins, which are members of the TGF-β superfamily, were initially isolated from gonads and served as modulators of follicle-stimulating hormone secretion. Activins regulate various biological functions, including induction of the dorsal mesoderm, craniofacial development, and differentiation of numerous cell types. Activin receptors are highly expressed in neuronal cells, and activin mRNA expression is upregulated by neuronal activity. Activins also exhibit neuroprotective action during excitotoxic brain injury. However, very little is known about the functional roles of activins in the brain. We recently generated various types of transgenic mice, demonstrating that activins regulate spine formation, behavioral activity, anxiety, adult neurogenesis, late-phase long-term potentiation, and maintenance of long-term memory. The present chapter describes recent progress in the study of the role of activin in the brain.
AB - Activins, which are members of the TGF-β superfamily, were initially isolated from gonads and served as modulators of follicle-stimulating hormone secretion. Activins regulate various biological functions, including induction of the dorsal mesoderm, craniofacial development, and differentiation of numerous cell types. Activin receptors are highly expressed in neuronal cells, and activin mRNA expression is upregulated by neuronal activity. Activins also exhibit neuroprotective action during excitotoxic brain injury. However, very little is known about the functional roles of activins in the brain. We recently generated various types of transgenic mice, demonstrating that activins regulate spine formation, behavioral activity, anxiety, adult neurogenesis, late-phase long-term potentiation, and maintenance of long-term memory. The present chapter describes recent progress in the study of the role of activin in the brain.
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U2 - 10.1016/B978-0-12-385961-7.00009-3
DO - 10.1016/B978-0-12-385961-7.00009-3
M3 - Article
C2 - 21353881
AN - SCOPUS:79951880175
SN - 0083-6729
VL - 85
SP - 185
EP - 206
JO - Vitamins and Hormones
JF - Vitamins and Hormones
ER -