Multifunctional Roles of Activins in the Brain

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Activins, which are members of the TGF-β superfamily, were initially isolated from gonads and served as modulators of follicle-stimulating hormone secretion. Activins regulate various biological functions, including induction of the dorsal mesoderm, craniofacial development, and differentiation of numerous cell types. Activin receptors are highly expressed in neuronal cells, and activin mRNA expression is upregulated by neuronal activity. Activins also exhibit neuroprotective action during excitotoxic brain injury. However, very little is known about the functional roles of activins in the brain. We recently generated various types of transgenic mice, demonstrating that activins regulate spine formation, behavioral activity, anxiety, adult neurogenesis, late-phase long-term potentiation, and maintenance of long-term memory. The present chapter describes recent progress in the study of the role of activin in the brain.

Original languageEnglish
Pages (from-to)185-206
Number of pages22
JournalVitamins and Hormones
Volume85
DOIs
Publication statusPublished - 28-02-2011

Fingerprint

Activins
Brain
Activin Receptors
Long-Term Memory
Long-Term Potentiation
Neurogenesis
Gonads
Follicle Stimulating Hormone
Mesoderm
Brain Injuries
Transgenic Mice
Cell Differentiation
Spine
Anxiety
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology

Cite this

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title = "Multifunctional Roles of Activins in the Brain",
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Multifunctional Roles of Activins in the Brain. / Ageta, Hiroshi; Tsuchida, Kunihiro.

In: Vitamins and Hormones, Vol. 85, 28.02.2011, p. 185-206.

Research output: Contribution to journalArticle

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