Mutation patterns for two flaviviruses: Hepatitis C virus and GB virus C/hepatitis G virus

Masashi Mizokami; Tadashi Imanishi; Kazuho Ikeo; Yoshiyuki Suzuki; Etsuro Orito; Takashi Kumada; Ryuzo Ueda; Shiro Iino; Tatsunori Nakano

doi:10.1016/S0014-5793(99)00507-4

Mutation patterns for two flaviviruses: Hepatitis C virus and GB virus C/hepatitis G virus

Masashi Mizokami, Tadashi Imanishi, Kazuho Ikeo, Yoshiyuki Suzuki, Etsuro Orito, Takashi Kumada, Ryuzo Ueda, Shiro Iino, Tatsunori Nakano

Internal Medicine

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

We studied the mutation patterns of hepatitis C virus (HCV) and GB virus C/hepatitis G virus (HGV). Although the mutation patterns of the two viruses were similar to each other, they were quite different from that of HIV. In particular, the similarity of the patterns between HCV or HGV and human nuclear pseudogenes was statistically significant whereas there was no similarity between HIV and human nuclear pseudogenes. This finding suggests that the mutation patterns of HCV and HGV are similar to the patterns of spontaneous substitution mutations of human genes, implying that nucleotide analogues which are effective against HCV and HGV may have a side effect on the normal cells of humans. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	294-298
Number of pages	5
Journal	FEBS Letters
Volume	450
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)00507-4
Publication status	Published - 07-05-1999

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Mizokami, M., Imanishi, T., Ikeo, K., Suzuki, Y., Orito, E., Kumada, T., Ueda, R., Iino, S., & Nakano, T. (1999). Mutation patterns for two flaviviruses: Hepatitis C virus and GB virus C/hepatitis G virus. FEBS Letters, 450(3), 294-298. https://doi.org/10.1016/S0014-5793(99)00507-4

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abstract = "We studied the mutation patterns of hepatitis C virus (HCV) and GB virus C/hepatitis G virus (HGV). Although the mutation patterns of the two viruses were similar to each other, they were quite different from that of HIV. In particular, the similarity of the patterns between HCV or HGV and human nuclear pseudogenes was statistically significant whereas there was no similarity between HIV and human nuclear pseudogenes. This finding suggests that the mutation patterns of HCV and HGV are similar to the patterns of spontaneous substitution mutations of human genes, implying that nucleotide analogues which are effective against HCV and HGV may have a side effect on the normal cells of humans. Copyright (C) 1999 Federation of European Biochemical Societies.",

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AU - Kumada, Takashi

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