Myocardial perfusion imaging with 99mTc-SQ30217: Application of three-headed SPECT system

K. Nakajima, J. Taki, H. Bunko, A. Muramori, I. Matunari, K. Konishi, K. Hisada, T. Ichihara

Research output: Contribution to journalArticle

Abstract

The early dynamic change of a new myocardial imaging agent, 99mTc-SQ30217, was investigated in SPECT study. A three-headed high sensitivity SPECT system was employed to evaluate the serial changes of accumulation pattern in the heart, lung and liver using a 'continuous repetitive acquisition' mode. The myocardial activity reached a peak rapidly and decreased with rapid clearance rate. The analysis of myocardial clearance curve showed a T( 1/2 ) of 2.8 minutes (k1 = 0.25 ± 0.12/min) in the rapid phase, and a T( 1/2 ) of 57 minutes (k2 = 0.012 ± 0.011/min) in the slow phase. The tracer clearance in the lung was more rapid, while the hepatic uptake reached a peak approximately 10 to 15 minutes after injection. When the serial SPECT images were reviewed, the early 3-minute acquisition within 10 minutes after injection showed better image quality than the images obtained after 10 minutes. The hepatic activity did not obscure the inferoseptal wall in the earlier images, but did in the images 10 minutes after injection. Thus, quick SPECT data acquisition seemed to be desirable for this agent. We concluded that 99mTc-SQ30217 was a promising radiopharmaceutical for myocardial perfusion imaging.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalKakuigaku
Volume28
Issue number2
Publication statusPublished - 01-01-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Nakajima, K., Taki, J., Bunko, H., Muramori, A., Matunari, I., Konishi, K., Hisada, K., & Ichihara, T. (1991). Myocardial perfusion imaging with 99mTc-SQ30217: Application of three-headed SPECT system. Kakuigaku, 28(2), 127-133.