Myocardial repolarization time, J-point to T-peak and T-peak to T-end intervals, have different heart rate dependency and autonomic nerve interference in healthy prepubertal children

Hirofumi Kusuki, Yuri Mizutani, Yuka Tsuchiya, Miki Nishio, Shota Oikawa, Rina Nagata, Yumi Kiriyanagi, Kayo Horio, Misa Hosoi, Hideaki Matsuura, Tsuneaki Sadanaga, Tadayoshi Hata

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The JT interval of the myocardial repolarization time can be divided into Jpoint to T-peak interval (JTp) and T-peak to T-end interval (Tpe). It is well known that the JT interval is dependent on the heart rate, but little is known regarding heart rate dependence for JTp and Tpe. The aim of the present study was to clarify the heart rate dependence of JTp and Tpe and to elucidate the interference of autonomic nervous activity with these parameters. Methods: We evaluated 50 prepubertal children (mean age: 6.4 ± 0.5 years; male:female, 22:28) without heart disease. JTp, Tpe, and the preceding RR intervals were measured using 120 consecutive beats (lead CM5). First, the relationships between the RR interval and JTp and Tpe were evaluated by Pearson's correlation coefficient. Second, to evaluate autonomic interference with JTp and Tpe, the degree of coherence between RR interval variability and JTp or Tpe variability was calculated using spectral analysis. Results: Significant positive correlations were observed between the RR interval and JTp (y = 0.116x + 105.5; r = 0.594, p < 0.001) and between the RR interval and Tpe (y = 0.037x + 44.7; r = 0.432, p < 0.001). Tpe variability had a lower degree of coherence with RR interval variability (range: 0.039–0.5 Hz) than with JTp variability (0.401 [interquartile range, 0.352–0.460] vs. 0.593 [0.503–0.664], respectively; p < 0.001). Conclusions: Tpe had lower heart rate dependence and a lower degree of autonomic nervous interference than did JTp.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalJournal of Electrocardiology
Volume67
DOIs
Publication statusPublished - 01-07-2021

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Myocardial repolarization time, J-point to T-peak and T-peak to T-end intervals, have different heart rate dependency and autonomic nerve interference in healthy prepubertal children'. Together they form a unique fingerprint.

Cite this