TY - JOUR
T1 - Myoinositol to total choline ratio in glioblastomas as a potential prognostic factor in preoperative magnetic resonance spectroscopy
AU - Kumon, Masanobu
AU - Nakae, Shunsuke
AU - Murayama, Kazuhiro
AU - Kato, Takema
AU - Ohba, Shigeo
AU - Inamasu, Joji
AU - Yamada, Seiji
AU - Abe, Masato
AU - Sasaki, Hikaru
AU - Ohno, Yoshiharu
AU - Hasegawa, Mitsuhiro
AU - Kurahashi, Hiroki
AU - Hirose, Yuichi
N1 - Publisher Copyright:
© 2021 The Japan Neurosurgical Society.
PY - 2021
Y1 - 2021
N2 - Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.
AB - Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.
KW - Glioblastoma
KW - Magnetic resonance spectroscopy
KW - Myoinositol
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U2 - 10.2176/nmc.oa.2020-0312
DO - 10.2176/nmc.oa.2020-0312
M3 - Article
C2 - 34078827
AN - SCOPUS:85114385917
SN - 0470-8105
VL - 61
SP - 453
EP - 460
JO - neurologia medico-chirurgica
JF - neurologia medico-chirurgica
IS - 8
ER -