TY - JOUR
T1 - Myoinositol to total choline ratio in glioblastomas as a potential prognostic factor in preoperative magnetic resonance spectroscopy
AU - Kumon, Masanobu
AU - Nakae, Shunsuke
AU - Murayama, Kazuhiro
AU - Kato, Takema
AU - Ohba, Shigeo
AU - Inamasu, Joji
AU - Yamada, Seiji
AU - Abe, Masato
AU - Sasaki, Hikaru
AU - Ohno, Yoshiharu
AU - Hasegawa, Mitsuhiro
AU - Kurahashi, Hiroki
AU - Hirose, Yuichi
N1 - Funding Information:
MK was the author and conducted this study. TK, HS, and HK conducted the copy number analysis and drafted the manuscript. KM and YO analyzed the metabolites of gliomas in this study and drafted the manuscript. MA and SY pathologically diagnosed the tissues according to the WHO classification. SN, SO, JI, MH, and YH revised and edited the manuscript. We would like to thank Ms. Fujiko Sueishi for her technical support. The study was funded by a Grant-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science and Technology in Japan (# 16K20029 to S.N.).
Publisher Copyright:
© 2021 The Japan Neurosurgical Society.
PY - 2021
Y1 - 2021
N2 - Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.
AB - Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.
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U2 - 10.2176/nmc.oa.2020-0312
DO - 10.2176/nmc.oa.2020-0312
M3 - Article
C2 - 34078827
AN - SCOPUS:85114385917
SN - 0387-2572
VL - 61
SP - 453
EP - 460
JO - Neurologia Medico-Chirurgica
JF - Neurologia Medico-Chirurgica
IS - 8
ER -