Myopathy in thiamine deficiency: Analysis of a case

Haruki Koike, Hirohisa Watanabe, Akira Inukai, Masahiro Iijima, Keiko Mori, Naoki Hattori, Gen Sobue

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Background: Tenderness in the limb muscles has been reported anecdotally in patients with beriberi neuropathy, but clinical effects of thiamine deficiency on skeletal muscle have received little attention. Objective: To describe a patient with thiamine deficiency who manifested myopathic symptoms and responded well to thiamine supplementation. Patient: A 26-year-old woman with neuropathy and heart failure associated with thiamine deficiency also complained of myalgia and weakness, most troublesome in the proximal portions of the limbs. Results: Serum creatine kinase, myoglobin, and aldolase concentrations were abnormally elevated. Magnetic resonance imaging of lower limb muscles demonstrated areas of high signal intensity in T2-weighted images and showed Gd-DTPA enhancement. A biopsy specimen from the quadriceps muscle showed myopathic changes without neurogenic changes. Abnormalities improved well with thiamine administration. Conclusion: Myopathy may occur in patients with thiamine deficiency.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalJournal of the Neurological Sciences
Issue number2
Publication statusPublished - 15-11-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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