Myosin II regulates extension, growth and patterning in the mammalian cochlear duct

Norio Yamamoto, Takayuki Okano, Xuefei Ma, Robert S. Adelstein, Matthew W. Kelley

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)


The sensory epithelium of the mammalian cochlea comprises mechanosensory hair cells that are arranged into four ordered rows extending along the length of the cochlear spiral. The factors that regulate the alignment of these rows are unknown. Results presented here demonstrate that cellular patterning within the cochlea, including the formation of ordered rows of hair cells, arises through morphological remodeling that is consistent with the mediolateral component of convergent extension. Non-muscle myosin II is shown to be expressed in a pattern that is consistent with an active role in cellular remodeling within the cochlea, and genetic or pharmacological inhibition of myosin II results in defects in cellular patterning that are consistent with a disruption in convergence and extension. These results identify the first molecule, myosin II, which directly regulates cellular patterning and alignment within the cochlear sensory epithelium. Our results also provide insights into the cellular mechanisms that are required for the formation of highly ordered cellular patterns.

Original languageEnglish
Pages (from-to)1977-1986
Number of pages10
Issue number12
Publication statusPublished - 15-06-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology


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