Nasal T‐cell lymphoma as a type of so‐called “lethal midline granuloma”

Yoshifumi Ishii, Noboru Yamanaka, Katsuhiro Ogawa, Yutaka Yoshida, Tsuyoshi Takami, Akihiro Matsuura, Hidemitsu Isago, Akikatsu Kataura, Kokichi Kikuchi

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127 Citations (Scopus)


Six cases were described in which an initial clinical diagnosis of “rhinitis gangrenosa progressiva” or lethal midline granuloma was made. The histological examinations of their surgical and autopsy specimens proved that their nasologic diseases could all be identified as malignant lymphoma arising from the nasal cavity, showing the general histologic characteristics reported for T‐cell lymphomata derived from peripheral T‐cells. This histologic observation was then confirmed by immunofluorescence studies using various antisera directed toward either human T‐ or B‐cell‐surface antigens. These studies clearly demonstrated that their malignant cells bore human Ly‐l‐like antigen but lacked human TL‐like and la‐like antigens as well as surface‐bound immunoglobulins, indicating their peripheral T‐cell origin. These data may suggest that so‐called “rhinitis gangrenosa progressiva” or lethal midline granuloma contains at least two distinct disease categories, one of which is Wegener's granulomatosis, and the other of which is nasal T‐cell lymphoma as described herein.

Original languageEnglish
Pages (from-to)2336-2344
Number of pages9
Issue number11
Publication statusPublished - 01-12-1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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