Background: We describe an exceedingly rare case of a nasopalatine duct cyst that developed after bone grafting into an alveolar cleft. Case presentation: A 10-year-old male patient with a unilateral lip and alveolar cleft underwent alveolar bone grafting. Computed tomography at the 1-year follow-up revealed a well-defined, round radiolucency including the grafted bone and the incisive canal. Cystectomy and bone grafting were performed, and the resected specimen was histopathologically diagnosed as a nasopalatine duct cyst. The postoperative course was good and bone bridging was achieved, including at the alveolar cleft. Conclusion: Based on our observations and the findings of previous reports, surgical stimulation due to alveolar bone grafting was suggested to have caused the NDC.
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