TY - JOUR
T1 - National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
T2 - I. The 2014 Diagnosis and Staging Working Group Report
AU - Jagasia, Madan H.
AU - Greinix, Hildegard T.
AU - Arora, Mukta
AU - Williams, Kirsten M.
AU - Wolff, Daniel
AU - Cowen, Edward W.
AU - Palmer, Jeanne
AU - Weisdorf, Daniel
AU - Treister, Nathaniel S.
AU - Cheng, Guang Shing
AU - Kerr, Holly
AU - Stratton, Pamela
AU - Duarte, Rafael F.
AU - McDonald, George B.
AU - Inamoto, Yoshihiro
AU - Vigorito, Afonso
AU - Arai, Sally
AU - Datiles, Manuel B.
AU - Jacobsohn, David
AU - Heller, Theo
AU - Kitko, Carrie L.
AU - Mitchell, Sandra A.
AU - Martin, Paul J.
AU - Shulman, Howard
AU - Wu, Roy S.
AU - Cutler, Corey S.
AU - Vogelsang, Georgia B.
AU - Lee, Stephanie J.
AU - Pavletic, Steven Z.
AU - Flowers, Mary E.D.
N1 - Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies.
AB - The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies.
UR - http://www.scopus.com/inward/record.url?scp=84922766049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922766049&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2014.12.001
DO - 10.1016/j.bbmt.2014.12.001
M3 - Article
C2 - 25529383
AN - SCOPUS:84922766049
SN - 1083-8791
VL - 21
SP - 389-401.e1
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 3
ER -