Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus

Hiroshi Hayami; Satoshi Takahashi; Kiyohito Ishikawa; Mitsuru Yasuda; Shingo Yamamoto; Shinya Uehara; Ryoichi Hamasuna; Tetsuro Matsumoto; Shinichi Minamitani; Akira Watanabe; Aikichi Iwamoto; Kyoichi Totsuka; Junichi Kadota; Keisuke Sunakawa; Junko Sato; Hideaki Hanaki; Taiji Tsukamoto; Hiroshi Kiyota; Shin Egawa; Kazushi Tanaka; Soichi Arakawa; Masato Fujisawa; Hiromi Kumon; Kanao Kobayashi; Akio Matsubara; Seiji Naito; Katsunori Tatsugami; Takamasa Yamaguchi; Shin Ito; Mototsugu Kanokogi; Harunori Narita; Hiromi Kawano; Takahide Hosobe; Kazuo Takayama; Toru Sumii; Akira Fujii; Takashi Sato; Takamine Yamauchi; Masanobu Izumitani; Hirofumi Chokyu; Hideari Ihara; Kikuo Akiyama; Masaru Yoshioka; Satoshi Uno; Koichi Monden; Motonori Kano; Shinichi Kaji; Shuichi Kawai; Kenji Ito; Hisato Inatomi; Hirofumi Nishimura; Toshihiro Ikuyama; Shohei Nishi; Koichi Takahashi; Yukihiro Kawano; Satoshi Ishihara; Kengo Tsuneyoshi; Shinji Matsushita; Takashi Yamane; Takaoki Hirose; Shigeru Fujihiro; Katsuhisa Endo; Yasuhiko Oka; Koh Takeyama; Takahiro Kimura; Tetsuji Uemura

doi:10.1007/s10156-013-0606-9

Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus

Hiroshi Hayami, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Shingo Yamamoto, Shinya Uehara, Ryoichi Hamasuna, Tetsuro Matsumoto, Shinichi Minamitani, Akira Watanabe, Aikichi Iwamoto, Kyoichi Totsuka, Junichi Kadota, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Kazushi TanakaSoichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Seiji Naito, Katsunori Tatsugami, Takamasa Yamaguchi, Shin Ito, Mototsugu Kanokogi, Harunori Narita, Hiromi Kawano, Takahide Hosobe, Kazuo Takayama, Toru Sumii, Akira Fujii, Takashi Sato, Takamine Yamauchi, Masanobu Izumitani, Hirofumi Chokyu, Hideari Ihara, Kikuo Akiyama, Masaru Yoshioka, Satoshi Uno, Koichi Monden, Motonori Kano, Shinichi Kaji, Shuichi Kawai, Kenji Ito, Hisato Inatomi, Hirofumi Nishimura, Toshihiro Ikuyama, Shohei Nishi, Koichi Takahashi, Yukihiro Kawano, Satoshi Ishihara, Kengo Tsuneyoshi, Shinji Matsushita, Takashi Yamane, Takaoki Hirose, Shigeru Fujihiro, Katsuhisa Endo, Yasuhiko Oka, Koh Takeyama, Takahiro Kimura, Tetsuji Uemura

Quality and Safety in Healthcare

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Abstract

The Japanese surveillance committee conducted the first nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for female acute uncomplicated cystitis at 43 hospitals throughout Japan from April 2009 to November 2010. In this study, the causative bacteria (Escherichia coli and Staphylococcus saprophyticus) and their susceptibility to various antimicrobial agents were investigated by isolation and culturing of bacteria from urine samples. In total, 387 strains were isolated from 461 patients, including E. coli (n = 301, 77.8 %), S. saprophyticus (n = 20, 5.2 %), Klebsiella pneumoniae (n = 13, 3.4 %), and Enterococcus faecalis (n = 11, 2.8 %). S. saprophyticus was significantly more common in premenopausal women (P = 0.00095). The minimum inhibitory concentrations of 19 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute manual. At least 87 % of E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, and 100 % of S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant E. coli strains and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 13.3 % and 4.7 %, respectively. It is important to confirm the susceptibility of causative bacteria for optimal antimicrobial therapy, and empiric antimicrobial agents should be selected by considering patient characteristics and other factors. However, the number of isolates of fluoroquinolone-resistant or ESBL-producing strains in gram-negative bacilli may be increasing in patients with urinary tract infections (UTIs) in Japan. Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies.

Original language	English
Pages (from-to)	393-403
Number of pages	11
Journal	Journal of Infection and Chemotherapy
Volume	19
Issue number	3
DOIs	https://doi.org/10.1007/s10156-013-0606-9
Publication status	Published - 06-2013

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hayami, H., Takahashi, S., Ishikawa, K., Yasuda, M., Yamamoto, S., Uehara, S., Hamasuna, R., Matsumoto, T., Minamitani, S., Watanabe, A., Iwamoto, A., Totsuka, K., Kadota, J., Sunakawa, K., Sato, J., Hanaki, H., Tsukamoto, T., Kiyota, H., Egawa, S., ... Uemura, T. (2013). Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus. Journal of Infection and Chemotherapy, 19(3), 393-403. https://doi.org/10.1007/s10156-013-0606-9

Hayami, Hiroshi ; Takahashi, Satoshi ; Ishikawa, Kiyohito et al. / Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010 : Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus. In: Journal of Infection and Chemotherapy. 2013 ; Vol. 19, No. 3. pp. 393-403.

@article{52cf7a0f86db4138abc2c04935d53070,

title = "Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus",

abstract = "The Japanese surveillance committee conducted the first nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for female acute uncomplicated cystitis at 43 hospitals throughout Japan from April 2009 to November 2010. In this study, the causative bacteria (Escherichia coli and Staphylococcus saprophyticus) and their susceptibility to various antimicrobial agents were investigated by isolation and culturing of bacteria from urine samples. In total, 387 strains were isolated from 461 patients, including E. coli (n = 301, 77.8 %), S. saprophyticus (n = 20, 5.2 %), Klebsiella pneumoniae (n = 13, 3.4 %), and Enterococcus faecalis (n = 11, 2.8 %). S. saprophyticus was significantly more common in premenopausal women (P = 0.00095). The minimum inhibitory concentrations of 19 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute manual. At least 87 % of E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, and 100 % of S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant E. coli strains and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 13.3 % and 4.7 %, respectively. It is important to confirm the susceptibility of causative bacteria for optimal antimicrobial therapy, and empiric antimicrobial agents should be selected by considering patient characteristics and other factors. However, the number of isolates of fluoroquinolone-resistant or ESBL-producing strains in gram-negative bacilli may be increasing in patients with urinary tract infections (UTIs) in Japan. Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies.",

author = "Hiroshi Hayami and Satoshi Takahashi and Kiyohito Ishikawa and Mitsuru Yasuda and Shingo Yamamoto and Shinya Uehara and Ryoichi Hamasuna and Tetsuro Matsumoto and Shinichi Minamitani and Akira Watanabe and Aikichi Iwamoto and Kyoichi Totsuka and Junichi Kadota and Keisuke Sunakawa and Junko Sato and Hideaki Hanaki and Taiji Tsukamoto and Hiroshi Kiyota and Shin Egawa and Kazushi Tanaka and Soichi Arakawa and Masato Fujisawa and Hiromi Kumon and Kanao Kobayashi and Akio Matsubara and Seiji Naito and Katsunori Tatsugami and Takamasa Yamaguchi and Shin Ito and Mototsugu Kanokogi and Harunori Narita and Hiromi Kawano and Takahide Hosobe and Kazuo Takayama and Toru Sumii and Akira Fujii and Takashi Sato and Takamine Yamauchi and Masanobu Izumitani and Hirofumi Chokyu and Hideari Ihara and Kikuo Akiyama and Masaru Yoshioka and Satoshi Uno and Koichi Monden and Motonori Kano and Shinichi Kaji and Shuichi Kawai and Kenji Ito and Hisato Inatomi and Hirofumi Nishimura and Toshihiro Ikuyama and Shohei Nishi and Koichi Takahashi and Yukihiro Kawano and Satoshi Ishihara and Kengo Tsuneyoshi and Shinji Matsushita and Takashi Yamane and Takaoki Hirose and Shigeru Fujihiro and Katsuhisa Endo and Yasuhiko Oka and Koh Takeyama and Takahiro Kimura and Tetsuji Uemura",

note = "Funding Information: Conflict of interest Akira Watanabe is a consultant to Daiichi-Sankyo, Mitsubishi Tanabe Pharma Corporation, Toyama Chemical, and Otsuka Pharmaceutical. A.W. has received a speaker{\textquoteright}s honorarium from MSD Japan, Glaxo SmithKline K.K., Shionogi & Co. Ltd., Daiichi-Sankyo, Taisho Toyama Pharmaceutical, Dainippon Sumitomo Pharma, and Pfizer Japan Inc.; and grant support from Kyorin Pharmaceutical, Shionogi & Co. Ltd., Taisho Pharmaceutical, Toy-ama Chemical, Daiichi-Sankyo, Dainippon Sumitomo Pharma, Taiho Pharma, and Meiji Seika Pharma. Keisuke Sunakawa has research grant for other research than this study from Meiji Seika Pharma Co., Ltd.",

year = "2013",

month = jun,

doi = "10.1007/s10156-013-0606-9",

language = "English",

volume = "19",

pages = "393--403",

journal = "Journal of Infection and Chemotherapy",

issn = "1341-321X",

publisher = "Elsevier BV",

number = "3",

}

Hayami, H, Takahashi, S, Ishikawa, K, Yasuda, M, Yamamoto, S, Uehara, S, Hamasuna, R, Matsumoto, T, Minamitani, S, Watanabe, A, Iwamoto, A, Totsuka, K, Kadota, J, Sunakawa, K, Sato, J, Hanaki, H, Tsukamoto, T, Kiyota, H, Egawa, S, Tanaka, K, Arakawa, S, Fujisawa, M, Kumon, H, Kobayashi, K, Matsubara, A, Naito, S, Tatsugami, K, Yamaguchi, T, Ito, S, Kanokogi, M, Narita, H, Kawano, H, Hosobe, T, Takayama, K, Sumii, T, Fujii, A, Sato, T, Yamauchi, T, Izumitani, M, Chokyu, H, Ihara, H, Akiyama, K, Yoshioka, M, Uno, S, Monden, K, Kano, M, Kaji, S, Kawai, S, Ito, K, Inatomi, H, Nishimura, H, Ikuyama, T, Nishi, S, Takahashi, K, Kawano, Y, Ishihara, S, Tsuneyoshi, K, Matsushita, S, Yamane, T, Hirose, T, Fujihiro, S, Endo, K, Oka, Y, Takeyama, K, Kimura, T & Uemura, T 2013, 'Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus', Journal of Infection and Chemotherapy, vol. 19, no. 3, pp. 393-403. https://doi.org/10.1007/s10156-013-0606-9

Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus. / Hayami, Hiroshi; Takahashi, Satoshi; Ishikawa, Kiyohito et al.
In: Journal of Infection and Chemotherapy, Vol. 19, No. 3, 06.2013, p. 393-403.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010

T2 - Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus

AU - Hayami, Hiroshi

AU - Takahashi, Satoshi

AU - Ishikawa, Kiyohito

AU - Yasuda, Mitsuru

AU - Yamamoto, Shingo

AU - Uehara, Shinya

AU - Hamasuna, Ryoichi

AU - Matsumoto, Tetsuro

AU - Minamitani, Shinichi

AU - Watanabe, Akira

AU - Iwamoto, Aikichi

AU - Totsuka, Kyoichi

AU - Kadota, Junichi

AU - Sunakawa, Keisuke

AU - Sato, Junko

AU - Hanaki, Hideaki

AU - Tsukamoto, Taiji

AU - Kiyota, Hiroshi

AU - Egawa, Shin

AU - Tanaka, Kazushi

AU - Arakawa, Soichi

AU - Fujisawa, Masato

AU - Kumon, Hiromi

AU - Kobayashi, Kanao

AU - Matsubara, Akio

AU - Naito, Seiji

AU - Tatsugami, Katsunori

AU - Yamaguchi, Takamasa

AU - Ito, Shin

AU - Kanokogi, Mototsugu

AU - Narita, Harunori

AU - Kawano, Hiromi

AU - Hosobe, Takahide

AU - Takayama, Kazuo

AU - Sumii, Toru

AU - Fujii, Akira

AU - Sato, Takashi

AU - Yamauchi, Takamine

AU - Izumitani, Masanobu

AU - Chokyu, Hirofumi

AU - Ihara, Hideari

AU - Akiyama, Kikuo

AU - Yoshioka, Masaru

AU - Uno, Satoshi

AU - Monden, Koichi

AU - Kano, Motonori

AU - Kaji, Shinichi

AU - Kawai, Shuichi

AU - Ito, Kenji

AU - Inatomi, Hisato

AU - Nishimura, Hirofumi

AU - Ikuyama, Toshihiro

AU - Nishi, Shohei

AU - Takahashi, Koichi

AU - Kawano, Yukihiro

AU - Ishihara, Satoshi

AU - Tsuneyoshi, Kengo

AU - Matsushita, Shinji

AU - Yamane, Takashi

AU - Hirose, Takaoki

AU - Fujihiro, Shigeru

AU - Endo, Katsuhisa

AU - Oka, Yasuhiko

AU - Takeyama, Koh

AU - Kimura, Takahiro

AU - Uemura, Tetsuji

N1 - Funding Information: Conflict of interest Akira Watanabe is a consultant to Daiichi-Sankyo, Mitsubishi Tanabe Pharma Corporation, Toyama Chemical, and Otsuka Pharmaceutical. A.W. has received a speaker’s honorarium from MSD Japan, Glaxo SmithKline K.K., Shionogi & Co. Ltd., Daiichi-Sankyo, Taisho Toyama Pharmaceutical, Dainippon Sumitomo Pharma, and Pfizer Japan Inc.; and grant support from Kyorin Pharmaceutical, Shionogi & Co. Ltd., Taisho Pharmaceutical, Toy-ama Chemical, Daiichi-Sankyo, Dainippon Sumitomo Pharma, Taiho Pharma, and Meiji Seika Pharma. Keisuke Sunakawa has research grant for other research than this study from Meiji Seika Pharma Co., Ltd.

PY - 2013/6

Y1 - 2013/6

N2 - The Japanese surveillance committee conducted the first nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for female acute uncomplicated cystitis at 43 hospitals throughout Japan from April 2009 to November 2010. In this study, the causative bacteria (Escherichia coli and Staphylococcus saprophyticus) and their susceptibility to various antimicrobial agents were investigated by isolation and culturing of bacteria from urine samples. In total, 387 strains were isolated from 461 patients, including E. coli (n = 301, 77.8 %), S. saprophyticus (n = 20, 5.2 %), Klebsiella pneumoniae (n = 13, 3.4 %), and Enterococcus faecalis (n = 11, 2.8 %). S. saprophyticus was significantly more common in premenopausal women (P = 0.00095). The minimum inhibitory concentrations of 19 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute manual. At least 87 % of E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, and 100 % of S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant E. coli strains and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 13.3 % and 4.7 %, respectively. It is important to confirm the susceptibility of causative bacteria for optimal antimicrobial therapy, and empiric antimicrobial agents should be selected by considering patient characteristics and other factors. However, the number of isolates of fluoroquinolone-resistant or ESBL-producing strains in gram-negative bacilli may be increasing in patients with urinary tract infections (UTIs) in Japan. Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies.

AB - The Japanese surveillance committee conducted the first nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for female acute uncomplicated cystitis at 43 hospitals throughout Japan from April 2009 to November 2010. In this study, the causative bacteria (Escherichia coli and Staphylococcus saprophyticus) and their susceptibility to various antimicrobial agents were investigated by isolation and culturing of bacteria from urine samples. In total, 387 strains were isolated from 461 patients, including E. coli (n = 301, 77.8 %), S. saprophyticus (n = 20, 5.2 %), Klebsiella pneumoniae (n = 13, 3.4 %), and Enterococcus faecalis (n = 11, 2.8 %). S. saprophyticus was significantly more common in premenopausal women (P = 0.00095). The minimum inhibitory concentrations of 19 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute manual. At least 87 % of E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, and 100 % of S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant E. coli strains and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 13.3 % and 4.7 %, respectively. It is important to confirm the susceptibility of causative bacteria for optimal antimicrobial therapy, and empiric antimicrobial agents should be selected by considering patient characteristics and other factors. However, the number of isolates of fluoroquinolone-resistant or ESBL-producing strains in gram-negative bacilli may be increasing in patients with urinary tract infections (UTIs) in Japan. Therefore, these data present important information for the proper treatment of UTIs and will serve as a useful reference for future surveillance studies.

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Hayami H, Takahashi S, Ishikawa K, Yasuda M, Yamamoto S, Uehara S et al. Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus. Journal of Infection and Chemotherapy. 2013 Jun;19(3):393-403. doi: 10.1007/s10156-013-0606-9

Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: Antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus

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