Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan

Satoshi Takahashi; Ryoichi Hamasuna; Mitsuru Yasuda; Kiyohito Ishikawa; Hiroshi Hayami; Shinya Uehara; Shingo Yamamoto; Shinichi Minamitani; Junichi Kadota; Satoshi Iwata; Mitsuo Kaku; Akira Watanabe; Junko Sato; Hideaki Hanaki; Naoya Masumori; Hiroshi Kiyota; Shin Egawa; Kazushi Tanaka; Soichi Arakawa; Masato Fujisawa; Hiromi Kumon; Koichiro Wada; Kanao Kobayashi; Akio Matsubara; Tetsuro Matsumoto; Masatoshi Eto; Katsunori Tatsugami; Kentaro Kuroiwa; Kenji Ito; Takahide Hosobe; Hideo Hirayama; Harunori Narita; Takamasa Yamaguchi; Shin Ito; Toru Sumii; Shuichi Kawai; Mototsugu Kanokogi; Hiromi Kawano; Hirofumi Chokyu; Satoshi Uno; Koichi Monden; Shinichi Kaji; Motoshi Kawahara; Kazuo Takayama; Masayasu Ito; Masaru Yoshioka; Motonori Kano; Takatoshi Konishi; Hitoshi Kadena; Shohei Nishi; Hirofumi Nishimura; Takamine Yamauchi; Shinichi Maeda; Masanobu Horie; Hideari Ihara; Masaru Matsumura; Takeshi Shirane; Koh Takeyama; Kikuo Akiyama; Koichi Takahashi; Toshihiro Ikuyama; Hisato Inatomi; Mutsumasa Yoh

doi:10.1016/j.jiac.2016.06.010

Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan

Satoshi Takahashi, Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Hiroshi Hayami, Shinya Uehara, Shingo Yamamoto, Shinichi Minamitani, Junichi Kadota, Satoshi Iwata, Mitsuo Kaku, Akira Watanabe, Junko Sato, Hideaki Hanaki, Naoya Masumori, Hiroshi Kiyota, Shin Egawa, Kazushi Tanaka, Soichi Arakawa, Masato FujisawaHiromi Kumon, Koichiro Wada, Kanao Kobayashi, Akio Matsubara, Tetsuro Matsumoto, Masatoshi Eto, Katsunori Tatsugami, Kentaro Kuroiwa, Kenji Ito, Takahide Hosobe, Hideo Hirayama, Harunori Narita, Takamasa Yamaguchi, Shin Ito, Toru Sumii, Shuichi Kawai, Mototsugu Kanokogi, Hiromi Kawano, Hirofumi Chokyu, Satoshi Uno, Koichi Monden, Shinichi Kaji, Motoshi Kawahara, Kazuo Takayama, Masayasu Ito, Masaru Yoshioka, Motonori Kano, Takatoshi Konishi, Hitoshi Kadena, Shohei Nishi, Hirofumi Nishimura, Takamine Yamauchi, Shinichi Maeda, Masanobu Horie, Hideari Ihara, Masaru Matsumura, Takeshi Shirane, Koh Takeyama, Kikuo Akiyama, Koichi Takahashi, Toshihiro Ikuyama, Hisato Inatomi, Mutsumasa Yoh

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Abstract

Genital chlamydial infection is a principal sexually transmitted infection worldwide. Chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. Fortunately, homotypic resistant C. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. In this surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 51 hospitals and clinics in 2009 and 38 in 2012. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 19 isolates in 2009 and 39 in 2012. In 2009 and 2012, the MICs (MIC₉₀) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, and azithromycin were 2 μg/ml and 1 μg/ml, 0.5 μg/ml and 0.5 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.063 μg/ml and 0.063 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.016 μg/ml and 0.016 μg/ml, and 0.063 μg/ml and 0.063 μg/ml, respectively. In summary, this surveillance project did not identify any resistant strain against fluoroquinolone, tetracycline, or macrolide agents in Japan.

Original language	English
Pages (from-to)	581-586
Number of pages	6
Journal	Journal of Infection and Chemotherapy
Volume	22
Issue number	9
DOIs	https://doi.org/10.1016/j.jiac.2016.06.010
Publication status	Published - 01-09-2016

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiac.2016.06.010

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Takahashi, S., Hamasuna, R., Yasuda, M., Ishikawa, K., Hayami, H., Uehara, S., Yamamoto, S., Minamitani, S., Kadota, J., Iwata, S., Kaku, M., Watanabe, A., Sato, J., Hanaki, H., Masumori, N., Kiyota, H., Egawa, S., Tanaka, K., Arakawa, S., ... Yoh, M. (2016). Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan. Journal of Infection and Chemotherapy, 22(9), 581-586. https://doi.org/10.1016/j.jiac.2016.06.010

@article{f13d3e4801e547c19bc13499b47049fc,

title = "Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan",

abstract = "Genital chlamydial infection is a principal sexually transmitted infection worldwide. Chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. Fortunately, homotypic resistant C. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. In this surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 51 hospitals and clinics in 2009 and 38 in 2012. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 19 isolates in 2009 and 39 in 2012. In 2009 and 2012, the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, and azithromycin were 2 μg/ml and 1 μg/ml, 0.5 μg/ml and 0.5 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.063 μg/ml and 0.063 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.016 μg/ml and 0.016 μg/ml, and 0.063 μg/ml and 0.063 μg/ml, respectively. In summary, this surveillance project did not identify any resistant strain against fluoroquinolone, tetracycline, or macrolide agents in Japan.",

keywords = "Antimicrobial susceptibility, Chlamydia trachomatis, Surveillance",

author = "Satoshi Takahashi and Ryoichi Hamasuna and Mitsuru Yasuda and Kiyohito Ishikawa and Hiroshi Hayami and Shinya Uehara and Shingo Yamamoto and Shinichi Minamitani and Junichi Kadota and Satoshi Iwata and Mitsuo Kaku and Akira Watanabe and Junko Sato and Hideaki Hanaki and Naoya Masumori and Hiroshi Kiyota and Shin Egawa and Kazushi Tanaka and Soichi Arakawa and Masato Fujisawa and Hiromi Kumon and Koichiro Wada and Kanao Kobayashi and Akio Matsubara and Tetsuro Matsumoto and Masatoshi Eto and Katsunori Tatsugami and Kentaro Kuroiwa and Kenji Ito and Takahide Hosobe and Hideo Hirayama and Harunori Narita and Takamasa Yamaguchi and Shin Ito and Toru Sumii and Shuichi Kawai and Mototsugu Kanokogi and Hiromi Kawano and Hirofumi Chokyu and Satoshi Uno and Koichi Monden and Shinichi Kaji and Motoshi Kawahara and Kazuo Takayama and Masayasu Ito and Masaru Yoshioka and Motonori Kano and Takatoshi Konishi and Hitoshi Kadena and Shohei Nishi and Hirofumi Nishimura and Takamine Yamauchi and Shinichi Maeda and Masanobu Horie and Hideari Ihara and Masaru Matsumura and Takeshi Shirane and Koh Takeyama and Kikuo Akiyama and Koichi Takahashi and Toshihiro Ikuyama and Hisato Inatomi and Mutsumasa Yoh",

note = "Publisher Copyright: {\textcopyright} 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases",

year = "2016",

month = sep,

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doi = "10.1016/j.jiac.2016.06.010",

language = "English",

volume = "22",

pages = "581--586",

journal = "Journal of Infection and Chemotherapy",

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Takahashi, S, Hamasuna, R, Yasuda, M, Ishikawa, K, Hayami, H, Uehara, S, Yamamoto, S, Minamitani, S, Kadota, J, Iwata, S, Kaku, M, Watanabe, A, Sato, J, Hanaki, H, Masumori, N, Kiyota, H, Egawa, S, Tanaka, K, Arakawa, S, Fujisawa, M, Kumon, H, Wada, K, Kobayashi, K, Matsubara, A, Matsumoto, T, Eto, M, Tatsugami, K, Kuroiwa, K, Ito, K, Hosobe, T, Hirayama, H, Narita, H, Yamaguchi, T, Ito, S, Sumii, T, Kawai, S, Kanokogi, M, Kawano, H, Chokyu, H, Uno, S, Monden, K, Kaji, S, Kawahara, M, Takayama, K, Ito, M, Yoshioka, M, Kano, M, Konishi, T, Kadena, H, Nishi, S, Nishimura, H, Yamauchi, T, Maeda, S, Horie, M, Ihara, H, Matsumura, M, Shirane, T, Takeyama, K, Akiyama, K, Takahashi, K, Ikuyama, T, Inatomi, H & Yoh, M 2016, 'Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan', Journal of Infection and Chemotherapy, vol. 22, no. 9, pp. 581-586. https://doi.org/10.1016/j.jiac.2016.06.010

TY - JOUR

T1 - Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan

AU - Takahashi, Satoshi

AU - Hamasuna, Ryoichi

AU - Yasuda, Mitsuru

AU - Ishikawa, Kiyohito

AU - Hayami, Hiroshi

AU - Uehara, Shinya

AU - Yamamoto, Shingo

AU - Minamitani, Shinichi

AU - Kadota, Junichi

AU - Iwata, Satoshi

AU - Kaku, Mitsuo

AU - Watanabe, Akira

AU - Sato, Junko

AU - Hanaki, Hideaki

AU - Masumori, Naoya

AU - Kiyota, Hiroshi

AU - Egawa, Shin

AU - Tanaka, Kazushi

AU - Arakawa, Soichi

AU - Fujisawa, Masato

AU - Kumon, Hiromi

AU - Wada, Koichiro

AU - Kobayashi, Kanao

AU - Matsubara, Akio

AU - Matsumoto, Tetsuro

AU - Eto, Masatoshi

AU - Tatsugami, Katsunori

AU - Kuroiwa, Kentaro

AU - Ito, Kenji

AU - Hosobe, Takahide

AU - Hirayama, Hideo

AU - Narita, Harunori

AU - Yamaguchi, Takamasa

AU - Ito, Shin

AU - Sumii, Toru

AU - Kawai, Shuichi

AU - Kanokogi, Mototsugu

AU - Kawano, Hiromi

AU - Chokyu, Hirofumi

AU - Uno, Satoshi

AU - Monden, Koichi

AU - Kaji, Shinichi

AU - Kawahara, Motoshi

AU - Takayama, Kazuo

AU - Ito, Masayasu

AU - Yoshioka, Masaru

AU - Kano, Motonori

AU - Konishi, Takatoshi

AU - Kadena, Hitoshi

AU - Nishi, Shohei

AU - Nishimura, Hirofumi

AU - Yamauchi, Takamine

AU - Maeda, Shinichi

AU - Horie, Masanobu

AU - Ihara, Hideari

AU - Matsumura, Masaru

AU - Shirane, Takeshi

AU - Takeyama, Koh

AU - Akiyama, Kikuo

AU - Takahashi, Koichi

AU - Ikuyama, Toshihiro

AU - Inatomi, Hisato

AU - Yoh, Mutsumasa

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Genital chlamydial infection is a principal sexually transmitted infection worldwide. Chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. Fortunately, homotypic resistant C. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. In this surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 51 hospitals and clinics in 2009 and 38 in 2012. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 19 isolates in 2009 and 39 in 2012. In 2009 and 2012, the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, and azithromycin were 2 μg/ml and 1 μg/ml, 0.5 μg/ml and 0.5 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.063 μg/ml and 0.063 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.016 μg/ml and 0.016 μg/ml, and 0.063 μg/ml and 0.063 μg/ml, respectively. In summary, this surveillance project did not identify any resistant strain against fluoroquinolone, tetracycline, or macrolide agents in Japan.

AB - Genital chlamydial infection is a principal sexually transmitted infection worldwide. Chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. Fortunately, homotypic resistant C. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. In this surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 51 hospitals and clinics in 2009 and 38 in 2012. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 19 isolates in 2009 and 39 in 2012. In 2009 and 2012, the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, and azithromycin were 2 μg/ml and 1 μg/ml, 0.5 μg/ml and 0.5 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.063 μg/ml and 0.063 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.016 μg/ml and 0.016 μg/ml, and 0.063 μg/ml and 0.063 μg/ml, respectively. In summary, this surveillance project did not identify any resistant strain against fluoroquinolone, tetracycline, or macrolide agents in Japan.

KW - Antimicrobial susceptibility

KW - Chlamydia trachomatis

KW - Surveillance

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U2 - 10.1016/j.jiac.2016.06.010

DO - 10.1016/j.jiac.2016.06.010

M3 - Article

C2 - 27452428

AN - SCOPUS:84979075835

SN - 1341-321X

VL - 22

SP - 581

EP - 586

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

IS - 9

ER -

Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan

Abstract

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