Nationwide survey of rotavirus-associated encephalopathy and sudden unexpected death in Japan

Yoshiki Kawamura, Masahiro Ohashi, Masaru Ihira, Shuji Hashimoto, Koki Taniguchi, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Rotavirus can cause severe complications such as encephalopathy/encephalitis and sudden unexpected death. The incidence of rotavirus-associated encephalopathy/encephalitis or sudden unexpected death remains unknown. To clarify the clinical features of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death, we conducted a nationwide survey in Japan. Method: A two-part questionnaire was designed to determine the number of the cases and the clinical features of severe cases of rotavirus infection, including encephalitis/encephalopathy and sudden unexpected death, between 2009 and 2011. Result: Of the 1365 questionnaires sent to hospitals, 963 (70.5%) were returned and eligible for analysis. We determined 58 cases of rotavirus-associated encephalitis/encephalopathy and 7 cases of sudden unexpected death. These patients were diagnosed with rotavirus infection by immunochromatography. Although 36/58 (62.1%) encephalitis/encephalopathy patients had no sequelae, 15/58 (25.9%) patients had neurological sequelae, and 7/58 (12.1%) patients had fatal outcomes. Pleocytosis was observed in 9/40 (22.5%) patients and cerebrospinal fluid protein levels were elevated in only 4/40 (10%) patients. Elevated lactate dehydrogenase (LDH) (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis. Conclusion: We estimate that annual cases of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death were 44.0 and 4.9 cases in Japan, respectively. Elevated LDH (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis of the encephalitis/encephalopathy.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalBrain and Development
Volume36
Issue number7
DOIs
Publication statusPublished - 01-01-2014

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Rotavirus
Brain Diseases
Encephalitis
Sudden Death
Japan
Rotavirus Infections
Immunochromatography
Cerebrospinal Fluid Proteins
Fatal Outcome
Leukocytosis
Surveys and Questionnaires
L-Lactate Dehydrogenase
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

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title = "Nationwide survey of rotavirus-associated encephalopathy and sudden unexpected death in Japan",
abstract = "Background: Rotavirus can cause severe complications such as encephalopathy/encephalitis and sudden unexpected death. The incidence of rotavirus-associated encephalopathy/encephalitis or sudden unexpected death remains unknown. To clarify the clinical features of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death, we conducted a nationwide survey in Japan. Method: A two-part questionnaire was designed to determine the number of the cases and the clinical features of severe cases of rotavirus infection, including encephalitis/encephalopathy and sudden unexpected death, between 2009 and 2011. Result: Of the 1365 questionnaires sent to hospitals, 963 (70.5{\%}) were returned and eligible for analysis. We determined 58 cases of rotavirus-associated encephalitis/encephalopathy and 7 cases of sudden unexpected death. These patients were diagnosed with rotavirus infection by immunochromatography. Although 36/58 (62.1{\%}) encephalitis/encephalopathy patients had no sequelae, 15/58 (25.9{\%}) patients had neurological sequelae, and 7/58 (12.1{\%}) patients had fatal outcomes. Pleocytosis was observed in 9/40 (22.5{\%}) patients and cerebrospinal fluid protein levels were elevated in only 4/40 (10{\%}) patients. Elevated lactate dehydrogenase (LDH) (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis. Conclusion: We estimate that annual cases of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death were 44.0 and 4.9 cases in Japan, respectively. Elevated LDH (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis of the encephalitis/encephalopathy.",
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Nationwide survey of rotavirus-associated encephalopathy and sudden unexpected death in Japan. / Kawamura, Yoshiki; Ohashi, Masahiro; Ihira, Masaru; Hashimoto, Shuji; Taniguchi, Koki; Yoshikawa, Tetsushi.

In: Brain and Development, Vol. 36, No. 7, 01.01.2014, p. 601-607.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nationwide survey of rotavirus-associated encephalopathy and sudden unexpected death in Japan

AU - Kawamura, Yoshiki

AU - Ohashi, Masahiro

AU - Ihira, Masaru

AU - Hashimoto, Shuji

AU - Taniguchi, Koki

AU - Yoshikawa, Tetsushi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Rotavirus can cause severe complications such as encephalopathy/encephalitis and sudden unexpected death. The incidence of rotavirus-associated encephalopathy/encephalitis or sudden unexpected death remains unknown. To clarify the clinical features of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death, we conducted a nationwide survey in Japan. Method: A two-part questionnaire was designed to determine the number of the cases and the clinical features of severe cases of rotavirus infection, including encephalitis/encephalopathy and sudden unexpected death, between 2009 and 2011. Result: Of the 1365 questionnaires sent to hospitals, 963 (70.5%) were returned and eligible for analysis. We determined 58 cases of rotavirus-associated encephalitis/encephalopathy and 7 cases of sudden unexpected death. These patients were diagnosed with rotavirus infection by immunochromatography. Although 36/58 (62.1%) encephalitis/encephalopathy patients had no sequelae, 15/58 (25.9%) patients had neurological sequelae, and 7/58 (12.1%) patients had fatal outcomes. Pleocytosis was observed in 9/40 (22.5%) patients and cerebrospinal fluid protein levels were elevated in only 4/40 (10%) patients. Elevated lactate dehydrogenase (LDH) (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis. Conclusion: We estimate that annual cases of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death were 44.0 and 4.9 cases in Japan, respectively. Elevated LDH (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis of the encephalitis/encephalopathy.

AB - Background: Rotavirus can cause severe complications such as encephalopathy/encephalitis and sudden unexpected death. The incidence of rotavirus-associated encephalopathy/encephalitis or sudden unexpected death remains unknown. To clarify the clinical features of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death, we conducted a nationwide survey in Japan. Method: A two-part questionnaire was designed to determine the number of the cases and the clinical features of severe cases of rotavirus infection, including encephalitis/encephalopathy and sudden unexpected death, between 2009 and 2011. Result: Of the 1365 questionnaires sent to hospitals, 963 (70.5%) were returned and eligible for analysis. We determined 58 cases of rotavirus-associated encephalitis/encephalopathy and 7 cases of sudden unexpected death. These patients were diagnosed with rotavirus infection by immunochromatography. Although 36/58 (62.1%) encephalitis/encephalopathy patients had no sequelae, 15/58 (25.9%) patients had neurological sequelae, and 7/58 (12.1%) patients had fatal outcomes. Pleocytosis was observed in 9/40 (22.5%) patients and cerebrospinal fluid protein levels were elevated in only 4/40 (10%) patients. Elevated lactate dehydrogenase (LDH) (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis. Conclusion: We estimate that annual cases of rotavirus-associated encephalitis/encephalopathy and sudden unexpected death were 44.0 and 4.9 cases in Japan, respectively. Elevated LDH (>500. IU/L) or acidemia (pH. <. 7.15) were related to a poor prognosis of the encephalitis/encephalopathy.

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DO - 10.1016/j.braindev.2013.07.013

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