Abstract
We have reported that the continuous infusion of β-amyloid protein-(1-40) into the rat cerebral ventricle produces learning and memory deficits accompanied by dysfunction in the cholinergic and dopaminergic systems. l-Pyroglutamyl-l-asparaginyl-l-seryl-l-prolyl-l-arginylglycinamide (NC-1900), an active fragment analog of arginine vasopressin in the rat brain, is a stable peptide with a five-fold longer half-life than that of arginine vasopressin-(4-9). In the present study, we examined the effects of NC-1900 on learning and memory deficits in β-amyloid protein-(1-40)-infused rats. The rats were injected subcutaneously with NC-1900 (0.1 and 1 ng kg-1) once a day throughout the period of behavioral examination. In the β-amyloid protein-infused rats, learning and memory in water maze and passive avoidance tasks were impaired compared with these in the control rats. NC-1900 prevented the learning and memory deficits in β-amyloid protein-infused rats. Moreover, NC-1900 tended to increase the choline acetyltransferase activity in the frontal cortex of the β-amyloid protein-infused rats. These results suggested that NC-1900 could be useful for the treatment of patients with Alzheimer's disease. Copyright (C) 1998 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 135-142 |
| Number of pages | 8 |
| Journal | European Journal of Pharmacology |
| Volume | 352 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 10-07-1998 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats. / Tanaka, Tomoko; Yamada, Kiyofumi; Senzaki, Kouji; Narimatsu, Hiroto; Nishimura, Kyoko; Kameyama, Tsutomu; Nabeshima, Toshitaka.
In: European Journal of Pharmacology, Vol. 352, No. 2-3, 10.07.1998, p. 135-142.Research output: Contribution to journal › Article
TY - JOUR
T1 - NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by β-amyloid protein in rats
AU - Tanaka, Tomoko
AU - Yamada, Kiyofumi
AU - Senzaki, Kouji
AU - Narimatsu, Hiroto
AU - Nishimura, Kyoko
AU - Kameyama, Tsutomu
AU - Nabeshima, Toshitaka
PY - 1998/7/10
Y1 - 1998/7/10
N2 - We have reported that the continuous infusion of β-amyloid protein-(1-40) into the rat cerebral ventricle produces learning and memory deficits accompanied by dysfunction in the cholinergic and dopaminergic systems. l-Pyroglutamyl-l-asparaginyl-l-seryl-l-prolyl-l-arginylglycinamide (NC-1900), an active fragment analog of arginine vasopressin in the rat brain, is a stable peptide with a five-fold longer half-life than that of arginine vasopressin-(4-9). In the present study, we examined the effects of NC-1900 on learning and memory deficits in β-amyloid protein-(1-40)-infused rats. The rats were injected subcutaneously with NC-1900 (0.1 and 1 ng kg-1) once a day throughout the period of behavioral examination. In the β-amyloid protein-infused rats, learning and memory in water maze and passive avoidance tasks were impaired compared with these in the control rats. NC-1900 prevented the learning and memory deficits in β-amyloid protein-infused rats. Moreover, NC-1900 tended to increase the choline acetyltransferase activity in the frontal cortex of the β-amyloid protein-infused rats. These results suggested that NC-1900 could be useful for the treatment of patients with Alzheimer's disease. Copyright (C) 1998 Elsevier Science B.V.
AB - We have reported that the continuous infusion of β-amyloid protein-(1-40) into the rat cerebral ventricle produces learning and memory deficits accompanied by dysfunction in the cholinergic and dopaminergic systems. l-Pyroglutamyl-l-asparaginyl-l-seryl-l-prolyl-l-arginylglycinamide (NC-1900), an active fragment analog of arginine vasopressin in the rat brain, is a stable peptide with a five-fold longer half-life than that of arginine vasopressin-(4-9). In the present study, we examined the effects of NC-1900 on learning and memory deficits in β-amyloid protein-(1-40)-infused rats. The rats were injected subcutaneously with NC-1900 (0.1 and 1 ng kg-1) once a day throughout the period of behavioral examination. In the β-amyloid protein-infused rats, learning and memory in water maze and passive avoidance tasks were impaired compared with these in the control rats. NC-1900 prevented the learning and memory deficits in β-amyloid protein-infused rats. Moreover, NC-1900 tended to increase the choline acetyltransferase activity in the frontal cortex of the β-amyloid protein-infused rats. These results suggested that NC-1900 could be useful for the treatment of patients with Alzheimer's disease. Copyright (C) 1998 Elsevier Science B.V.
UR - http://www.scopus.com/inward/record.url?scp=0031879794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031879794&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(98)00344-6
DO - 10.1016/S0014-2999(98)00344-6
M3 - Article
VL - 352
SP - 135
EP - 142
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -