Nectin1 expression is frequently decreased in gastric cancers

Yu Takahashi, Nobutake Yamamichi, Ken ichi Inada, Kazuya Shiogama, Kouhei Sakurai, Chihiro Takeuchi, Yasuyoshi Mizutani, Yutaka Tsutsumi, Kazuhiko Koike

Research output: Contribution to journalArticle

Abstract

Gastric cancer (GC) is rich in many different histological types, but how the histological pattern is defined remains to be proved. The relation between GC histological types and the expression of nectin1, which is one of the cell adhesion molecules that composes adherens junction, has not been reported. According to a publicly available database of 406 GC patients, the median overall survival of Nectin1 high expression patients was 55.4 months and that of low expression patients was 25.6 months (P = 0.0246). Using surgically or endoscopically resected GC samples, nectin1 expression was analyzed by immunohistochemistry. Nectin1 expressed at adherens junction in all the normal epithelial cells. However, nectin1 expressed not at adherens junction but at apical membrane in epithelial cells in intestinal metaplasia. The expression pattern of nectin1 in intestinal type GC resembled to intestinal metaplasia. In order to analyze the difference in nectin1 expression between GC histological types, a total of 116 intestinal type GC and 33 diffuse type GC. The expression of necitin1 in diffuse type GC (3.0%) was remarkably decreased compared to that in intestinal type GC (65.5%) (P < 0.0001). In conclusion, this is the first report showing an association between nectin1 expression and histological subtypes of GC.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalPathology International
Volume68
Issue number10
DOIs
Publication statusPublished - 10-2018

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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    Takahashi, Y., Yamamichi, N., Inada, K. I., Shiogama, K., Sakurai, K., Takeuchi, C., Mizutani, Y., Tsutsumi, Y., & Koike, K. (2018). Nectin1 expression is frequently decreased in gastric cancers. Pathology International, 68(10), 557-562. https://doi.org/10.1111/pin.12721