Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats

Yijin Yan, Tomoko Mizuno, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Nefiracetam has been reported to increase intracellular cyclic AMP levels and enhance calcium channel current. Since the cAMP cascade is involved in the development of drug dependence, we investigated whether nefiracetam attenuates the methamphetamine (MAP)-induced discriminative responses in rats. Nefiracetam (50 mg/kg) inhibited MAP-induced discriminative responses. Furthermore, rolipram, raclopride, and L-745870, all of which can enhance cAMP activity, disrupted MAP-paired lever press of rats. Nifedipine and neomycin, which are blockers of voltage-sensitive calcium channels (VSCCs), decreased MAP-induced discriminative responses. However, pretreatment of these VSCC blockers failed to affect the inhibitory effects of nefiracetem on MAP-induced discriminative responses. Our findings suggested that nefiracetam inhibits MAP-induced discriminative responses, which may be at least partly associated with the changes in intracellular cAMP levels.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1025
DOIs
Publication statusPublished - 01-01-2004
Externally publishedYes

Fingerprint

Methamphetamine
Rats
Calcium Channels
3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine
Rolipram
Raclopride
Neomycin
Calcium Channel Blockers
Electric potential
Nifedipine
Cyclic AMP
Substance-Related Disorders
nefiracetam
Stimulus
Rat
Calcium
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Yan, Yijin ; Mizuno, Tomoko ; Nitta, Atsumi ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats. In: Annals of the New York Academy of Sciences. 2004 ; Vol. 1025. pp. 274-278.
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Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats. / Yan, Yijin; Mizuno, Tomoko; Nitta, Atsumi; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Annals of the New York Academy of Sciences, Vol. 1025, 01.01.2004, p. 274-278.

Research output: Contribution to journalArticle

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