Nefiracetam induces a long-lasting facilitation of hippocampal postsynaptic responses in mice lacking the NMDA receptor ε1 subunit

Shinji Matsumoto, Takeshi Kanno, Tamotsu Nomura, Tadashi Shiotani, Sigeo Watabe, Toshitaka Nabeshima, Tomoyuki Nishizaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The present study was designed to assess whether the facilitatory action of nefiracetam, a pyrrolidone derivative, on hippocampal postsynaptic responses is dependent upon N-methyl-D-aspartate (NMDA) receptors or not, by monitoring population spikes (PSs) in the dentate gyrus of hippocampal slices from mice lacking the NMDA receptor ε1 subunit. Nefiracetam (1 μM) induced a sustained facilitation of postsynaptic responses in the dentate gyrus of hippocampal slices from wild-type mice. The facilitation occluded the potentiation induced by high-frequency stimulation at the perforant path, and vice versa, suggesting a common mechanism between them. The perforant path long-term potentiation (LTP) was not induce in ε1 subunit knock-out mice, but nefiracetam (1 μM) persistently potentiated PS amplitude, reaching 280% of basal levels 50 min after 10-min treatment, similar to the potentiation achieved with wild-type mice. The results of the present study, thus, suggest that nefiracetam exerts its facilitatory action on hippocampal postsynaptic responses in an NMDA receptor-independent manner.

Original languageEnglish
Pages (from-to)178-181
Number of pages4
JournalBrain Research
Volume956
Issue number1
DOIs
Publication statusPublished - 22-11-2002

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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