TY - JOUR
T1 - Nefiracetam induces a long-lasting facilitation of hippocampal postsynaptic responses in mice lacking the NMDA receptor ε1 subunit
AU - Matsumoto, Shinji
AU - Kanno, Takeshi
AU - Nomura, Tamotsu
AU - Shiotani, Tadashi
AU - Watabe, Sigeo
AU - Nabeshima, Toshitaka
AU - Nishizaki, Tomoyuki
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/11/22
Y1 - 2002/11/22
N2 - The present study was designed to assess whether the facilitatory action of nefiracetam, a pyrrolidone derivative, on hippocampal postsynaptic responses is dependent upon N-methyl-D-aspartate (NMDA) receptors or not, by monitoring population spikes (PSs) in the dentate gyrus of hippocampal slices from mice lacking the NMDA receptor ε1 subunit. Nefiracetam (1 μM) induced a sustained facilitation of postsynaptic responses in the dentate gyrus of hippocampal slices from wild-type mice. The facilitation occluded the potentiation induced by high-frequency stimulation at the perforant path, and vice versa, suggesting a common mechanism between them. The perforant path long-term potentiation (LTP) was not induce in ε1 subunit knock-out mice, but nefiracetam (1 μM) persistently potentiated PS amplitude, reaching 280% of basal levels 50 min after 10-min treatment, similar to the potentiation achieved with wild-type mice. The results of the present study, thus, suggest that nefiracetam exerts its facilitatory action on hippocampal postsynaptic responses in an NMDA receptor-independent manner.
AB - The present study was designed to assess whether the facilitatory action of nefiracetam, a pyrrolidone derivative, on hippocampal postsynaptic responses is dependent upon N-methyl-D-aspartate (NMDA) receptors or not, by monitoring population spikes (PSs) in the dentate gyrus of hippocampal slices from mice lacking the NMDA receptor ε1 subunit. Nefiracetam (1 μM) induced a sustained facilitation of postsynaptic responses in the dentate gyrus of hippocampal slices from wild-type mice. The facilitation occluded the potentiation induced by high-frequency stimulation at the perforant path, and vice versa, suggesting a common mechanism between them. The perforant path long-term potentiation (LTP) was not induce in ε1 subunit knock-out mice, but nefiracetam (1 μM) persistently potentiated PS amplitude, reaching 280% of basal levels 50 min after 10-min treatment, similar to the potentiation achieved with wild-type mice. The results of the present study, thus, suggest that nefiracetam exerts its facilitatory action on hippocampal postsynaptic responses in an NMDA receptor-independent manner.
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U2 - 10.1016/S0006-8993(02)03556-4
DO - 10.1016/S0006-8993(02)03556-4
M3 - Article
C2 - 12426061
AN - SCOPUS:0037159639
SN - 0006-8993
VL - 956
SP - 178
EP - 181
JO - Brain Research
JF - Brain Research
IS - 1
ER -