TY - JOUR
T1 - Neglect-induced pseudo-thrombotic thrombocytopenic purpura due to vitamin B12 deficiency
AU - Asano, Takeshi
AU - Narazaki, Hidehiko
AU - Kaizu, Kiyohiko
AU - Matsukawa, Shouhei
AU - Takema-Tochikubo, Yuki
AU - Fujii, Shuichi
AU - Saitoh, Nobuyuki
AU - Mashiko, Kunihiko
AU - Fujino, Osamu
N1 - Publisher Copyright:
© 2015 Japan Pediatric Society.
PY - 2015/10
Y1 - 2015/10
N2 - Although thrombotic thrombocytopenic purpura (TTP) is rare, early diagnosis and treatment are important for decreasing the mortality rate. Acquired vitamin B12 deficiency is frequently overlooked because of its rarity in developed countries, particularly in children and adolescents. The hematological changes in vitamin B12 deficiency present as megaloblastic anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia and thrombocytopenia. We report herein the case of a 15-year-old girl who had been neglected, which might have caused pseudo-TTP through malnutrition, particularly vitamin B12 deficiency. When we encounter cases of TTP in children, clinicians must be aware of the possibility of malnutrition, particularly with vitamin B12 deficiency, even in developed countries, and investigate the cause of malnutrition including neglect.
AB - Although thrombotic thrombocytopenic purpura (TTP) is rare, early diagnosis and treatment are important for decreasing the mortality rate. Acquired vitamin B12 deficiency is frequently overlooked because of its rarity in developed countries, particularly in children and adolescents. The hematological changes in vitamin B12 deficiency present as megaloblastic anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia and thrombocytopenia. We report herein the case of a 15-year-old girl who had been neglected, which might have caused pseudo-TTP through malnutrition, particularly vitamin B12 deficiency. When we encounter cases of TTP in children, clinicians must be aware of the possibility of malnutrition, particularly with vitamin B12 deficiency, even in developed countries, and investigate the cause of malnutrition including neglect.
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U2 - 10.1111/ped.12718
DO - 10.1111/ped.12718
M3 - Article
C2 - 26387768
AN - SCOPUS:84983134962
SN - 1328-8067
VL - 57
SP - 988
EP - 990
JO - Pediatrics International
JF - Pediatrics International
IS - 5
ER -