Neointima formation in a restenosis model is suppressed in midkine- deficient mice

Mitsuru Horiba, Kenji Kadomatsu, Eishin Nakamura, Hisako Muramatsu, Shinya Ikematsu, Sadatoshi Sakuma, Kenji Hayashi, Yukio Yuzawa, Seiichi Matsuo, Masafumi Kuzuya, Tadashi Kaname, Makoto Hirai, Hidehiko Saito, Takashi Muramatsu

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Neointima formation is a common feature of atherosclerosis and restenosis after balloon angioplasty. To find a new target to suppress neointima formation, we investigated the possible role of midkine (MK), a heparin-binding growth factor with neurotrophic and chemotactic activities, in neointima formation. MK expression increased during neointima formation caused by intraluminal balloon injury of the rat carotid artery. Neointima formation in a restenosis model was strongly suppressed in MK-deficient mice. Continuous administration of MK protein to MK-deficient mice restored neointima formation. Leukocyte recruitment to the vascular walls after injury was markedly decreased in MK-deficient mice. Soluble MK as well as that bound to the substratum induced migration of macrophages in vitro. These results indicate that MK plays a critical role in neointima formation at least in part owing to its ability to mediate leukocyte recruitment.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalJournal of Clinical Investigation
Volume105
Issue number4
DOIs
Publication statusPublished - 01-01-2000
Externally publishedYes

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Neointima
Leukocytes
Carotid Artery Injuries
Balloon Angioplasty
midkine
Blood Vessels
Heparin
Atherosclerosis
Intercellular Signaling Peptides and Proteins
Macrophages
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Horiba, M., Kadomatsu, K., Nakamura, E., Muramatsu, H., Ikematsu, S., Sakuma, S., ... Muramatsu, T. (2000). Neointima formation in a restenosis model is suppressed in midkine- deficient mice. Journal of Clinical Investigation, 105(4), 489-495. https://doi.org/10.1172/JCI7208
Horiba, Mitsuru ; Kadomatsu, Kenji ; Nakamura, Eishin ; Muramatsu, Hisako ; Ikematsu, Shinya ; Sakuma, Sadatoshi ; Hayashi, Kenji ; Yuzawa, Yukio ; Matsuo, Seiichi ; Kuzuya, Masafumi ; Kaname, Tadashi ; Hirai, Makoto ; Saito, Hidehiko ; Muramatsu, Takashi. / Neointima formation in a restenosis model is suppressed in midkine- deficient mice. In: Journal of Clinical Investigation. 2000 ; Vol. 105, No. 4. pp. 489-495.
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Horiba, M, Kadomatsu, K, Nakamura, E, Muramatsu, H, Ikematsu, S, Sakuma, S, Hayashi, K, Yuzawa, Y, Matsuo, S, Kuzuya, M, Kaname, T, Hirai, M, Saito, H & Muramatsu, T 2000, 'Neointima formation in a restenosis model is suppressed in midkine- deficient mice', Journal of Clinical Investigation, vol. 105, no. 4, pp. 489-495. https://doi.org/10.1172/JCI7208

Neointima formation in a restenosis model is suppressed in midkine- deficient mice. / Horiba, Mitsuru; Kadomatsu, Kenji; Nakamura, Eishin; Muramatsu, Hisako; Ikematsu, Shinya; Sakuma, Sadatoshi; Hayashi, Kenji; Yuzawa, Yukio; Matsuo, Seiichi; Kuzuya, Masafumi; Kaname, Tadashi; Hirai, Makoto; Saito, Hidehiko; Muramatsu, Takashi.

In: Journal of Clinical Investigation, Vol. 105, No. 4, 01.01.2000, p. 489-495.

Research output: Contribution to journalArticle

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AU - Hirai, Makoto

AU - Saito, Hidehiko

AU - Muramatsu, Takashi

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Horiba M, Kadomatsu K, Nakamura E, Muramatsu H, Ikematsu S, Sakuma S et al. Neointima formation in a restenosis model is suppressed in midkine- deficient mice. Journal of Clinical Investigation. 2000 Jan 1;105(4):489-495. https://doi.org/10.1172/JCI7208