Nephrotic syndrome with massive accumulation of type I and type III collagen in the glomeruli

Futoshi Yoshida, Yukio Yuzawa, Seiichi Matsuo, Hidekazu Shigematsu, Akira Ito, Chikao Yamazaki, Kazuo Yoshioka, Akira Ooshima

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21 Citations (Scopus)

Abstract

A 54-year-old woman with nephrotic syndrome underwent renal biopsy. By light microscopy, the glomerular capillary lumen was remarkably narrowed because of diffuse accumulation of Periodic acid Shiff (PAS) positive material along the glomerular capillary wall. By electron microscopy, collagenous fibers were observed in the mesangium and subendothelial area. The fibrous material reacted with antibodies against type I and III collagen but not with those against laminin or type IV collagen by an indirect immunofluorescence technique. This case seemed to be a case of collagenofibrotic glomerulonephropathy.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalInternal Medicine
Volume32
Issue number2
DOIs
Publication statusPublished - 01-01-1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Yoshida, F., Yuzawa, Y., Matsuo, S., Shigematsu, H., Ito, A., Yamazaki, C., Yoshioka, K., & Ooshima, A. (1993). Nephrotic syndrome with massive accumulation of type I and type III collagen in the glomeruli. Internal Medicine, 32(2), 171-176. https://doi.org/10.2169/internalmedicine.32.171