Neural stem cells suppress the hearing threshold shift caused by cochlear ischemia

Nobuhiro Hakuba, Ryuji Hata, Isamu Morizane, Gu Feng, Yoshitaka Shimizu, Kensuke Fujita, Tadashi Yoshida, Masahiro Sakanaka, Kiyofumi Gyo

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Neural stem cells are multipotent progenitor cells that show self-renewal activity. In this study, we assessed the use of neural stem cells for ameliorating ischemia-reperfusion injury of the gerbil cochlea. Neural stem cells were injected into one inner ear through the round window I day after ischemic insult. Immunostaining for nestin showed that the distribution of neural stem cells was concentrated within the organ of Corti. Seven days after ischemia, the injury-induced auditory brainstem response threshold shift and progressive inner hair cell damage were markedly less on the neural stem cell-transplanted side. These results suggest that the transplantation of neural stem cells is therapeutically useful for preventing damage to hair cells that occurs after transient ischemia of the cochlea.

Original languageEnglish
Pages (from-to)1545-1549
Number of pages5
Issue number14
Publication statusPublished - 28-09-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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