Abstract
Neural stem cells are multipotent progenitor cells that show self-renewal activity. In this study, we assessed the use of neural stem cells for ameliorating ischemia-reperfusion injury of the gerbil cochlea. Neural stem cells were injected into one inner ear through the round window I day after ischemic insult. Immunostaining for nestin showed that the distribution of neural stem cells was concentrated within the organ of Corti. Seven days after ischemia, the injury-induced auditory brainstem response threshold shift and progressive inner hair cell damage were markedly less on the neural stem cell-transplanted side. These results suggest that the transplantation of neural stem cells is therapeutically useful for preventing damage to hair cells that occurs after transient ischemia of the cochlea.
| Original language | English |
|---|---|
| Pages (from-to) | 1545-1549 |
| Number of pages | 5 |
| Journal | Neuroreport |
| Volume | 16 |
| Issue number | 14 |
| Publication status | Published - 28-09-2005 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Neuroscience