TY - JOUR
T1 - Neuroblastoma Growth Factors Derived from Neurofibroma (NF1)
T2 - Participation of Uridine in a Neuroblastoma Growth
AU - Hotta, Taeko
AU - Asai, Kiyofumi
AU - Takeda, Naohito
AU - Tatematsu, Akira
AU - Nakanishi, Keiko
AU - Eksioglu, Yaman Z.
AU - Isobe, Ichiro
AU - Kato, Taiji
PY - 1993/1
Y1 - 1993/1
N2 - Abstract: Human glioma cell extracts were found to elicit a marked growth‐promoting activity on human neuroblastoma cells. This activity was also detected in the extracts of neurofibroma type 1 (NF1; von Recklinghausen neurofibromatosis) comprising aberrant Schwann cell growth. The purified substance from the NF1 extracts by HPLC on ODS columns was identical to a pyrimidine nucleoside, uridine, the chemical structure of which was identified by gas chromatography‐mass spectrometry. The authentic uridine showed a strong growth‐promoting activity on human neuroblastoma cells. Other purine or pyrimidine nucleotides, their derivatives, and ribose sources for their syntheses were employed to test the activity; a purine nucleoside, adenosine, showed a stronger activity than uridine. The current study raises the possibility that human neuroblastoma cells may be affected by dysfunctions of the de novo pathway of both purine and pyrimidine nucleotide biosyntheses.
AB - Abstract: Human glioma cell extracts were found to elicit a marked growth‐promoting activity on human neuroblastoma cells. This activity was also detected in the extracts of neurofibroma type 1 (NF1; von Recklinghausen neurofibromatosis) comprising aberrant Schwann cell growth. The purified substance from the NF1 extracts by HPLC on ODS columns was identical to a pyrimidine nucleoside, uridine, the chemical structure of which was identified by gas chromatography‐mass spectrometry. The authentic uridine showed a strong growth‐promoting activity on human neuroblastoma cells. Other purine or pyrimidine nucleotides, their derivatives, and ribose sources for their syntheses were employed to test the activity; a purine nucleoside, adenosine, showed a stronger activity than uridine. The current study raises the possibility that human neuroblastoma cells may be affected by dysfunctions of the de novo pathway of both purine and pyrimidine nucleotide biosyntheses.
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U2 - 10.1111/j.1471-4159.1993.tb05853.x
DO - 10.1111/j.1471-4159.1993.tb05853.x
M3 - Article
C2 - 8417151
AN - SCOPUS:0027390119
SN - 0022-3042
VL - 60
SP - 312
EP - 319
JO - Journal of neurochemistry
JF - Journal of neurochemistry
IS - 1
ER -