Neuroblastoma Growth Factors Derived from Neurofibroma (NF1): Participation of Uridine in a Neuroblastoma Growth

Taeko Hotta, Kiyofumi Asai, Naohito Takeda, Akira Tatematsu, Keiko Nakanishi, Yaman Z. Eksioglu, Ichiro Isobe, Taiji Kato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Abstract: Human glioma cell extracts were found to elicit a marked growth‐promoting activity on human neuroblastoma cells. This activity was also detected in the extracts of neurofibroma type 1 (NF1; von Recklinghausen neurofibromatosis) comprising aberrant Schwann cell growth. The purified substance from the NF1 extracts by HPLC on ODS columns was identical to a pyrimidine nucleoside, uridine, the chemical structure of which was identified by gas chromatography‐mass spectrometry. The authentic uridine showed a strong growth‐promoting activity on human neuroblastoma cells. Other purine or pyrimidine nucleotides, their derivatives, and ribose sources for their syntheses were employed to test the activity; a purine nucleoside, adenosine, showed a stronger activity than uridine. The current study raises the possibility that human neuroblastoma cells may be affected by dysfunctions of the de novo pathway of both purine and pyrimidine nucleotide biosyntheses.

Original languageEnglish
Pages (from-to)312-319
Number of pages8
JournalJournal of neurochemistry
Volume60
Issue number1
DOIs
Publication statusPublished - 01-1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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