Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-d-aspartate-induced aversive behavior

Yohko Maeda, Kiyofumi Yamada, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To elucidate the mechanism of antinociceptive effects of calcitonin, we investigated whether receptor antagonists for various neurotransmitter receptors alter the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice. Neither naloxone, an opioid receptor antagonist, phentolamine and benextramine, α-adrenoceptor antagonists, nor ritanserin, a 5-HT2A receptor antagonist, inhibited the calcitonin-induced anti-aversive effects. Pindolol and (-)-propranolol, non-selective antagonists of β-adrenoceptors and 5-HT1 receptors, 1-(2-methoxyphenyl)-4-[4-(2-phethalimido) butyl]-piperazine hydrobromide (NAN-190), a 5-HT1A receptor antagonist, 3-tropanyl-3,5-dichlorobenzoate (MDL72222) and metoclopramide, 5-HT3 receptor antagonists, significantly inhibited the calcitonin-induced anti-aversive effects. (-)-Bicuculline, a GABAA receptor antagonist, phaclofen and 5-aminovaleric acid, GABAB receptor antagonists, also attenuated the calcitonin-induced anti-aversive effects. These results suggest that β-adrenoceptor, 5-HT1A, 5-HT3, GABAA and GABAB receptors, but not α-adrenoceptor, opioid nor 5-HT2A receptors, are involved in the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalEuropean Journal of Pharmacology
Volume275
Issue number2
DOIs
Publication statusPublished - 06-03-1995
Externally publishedYes

Fingerprint

Calcitonin
Aspartic Acid
Adrenergic Receptors
Receptor, Serotonin, 5-HT2A
Serotonin 5-HT1 Receptors
Ritanserin
Serotonin 5-HT1 Receptor Antagonists
Serotonin 5-HT3 Receptor Antagonists
Serotonin 5-HT2 Receptor Antagonists
GABA-A Receptor Antagonists
Pindolol
Receptors, Serotonin, 5-HT3
Metoclopramide
Neurotransmitter Receptor
Receptor, Serotonin, 5-HT1A
Bicuculline
Narcotic Antagonists
Phentolamine
GABA-A Receptors
Propranolol

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{5419ed5daf694fb9a4976f888d421837,
title = "Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-d-aspartate-induced aversive behavior",
abstract = "To elucidate the mechanism of antinociceptive effects of calcitonin, we investigated whether receptor antagonists for various neurotransmitter receptors alter the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice. Neither naloxone, an opioid receptor antagonist, phentolamine and benextramine, α-adrenoceptor antagonists, nor ritanserin, a 5-HT2A receptor antagonist, inhibited the calcitonin-induced anti-aversive effects. Pindolol and (-)-propranolol, non-selective antagonists of β-adrenoceptors and 5-HT1 receptors, 1-(2-methoxyphenyl)-4-[4-(2-phethalimido) butyl]-piperazine hydrobromide (NAN-190), a 5-HT1A receptor antagonist, 3-tropanyl-3,5-dichlorobenzoate (MDL72222) and metoclopramide, 5-HT3 receptor antagonists, significantly inhibited the calcitonin-induced anti-aversive effects. (-)-Bicuculline, a GABAA receptor antagonist, phaclofen and 5-aminovaleric acid, GABAB receptor antagonists, also attenuated the calcitonin-induced anti-aversive effects. These results suggest that β-adrenoceptor, 5-HT1A, 5-HT3, GABAA and GABAB receptors, but not α-adrenoceptor, opioid nor 5-HT2A receptors, are involved in the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice.",
author = "Yohko Maeda and Kiyofumi Yamada and Takaaki Hasegawa and Toshitaka Nabeshima",
year = "1995",
month = "3",
day = "6",
doi = "10.1016/0014-2999(94)00764-X",
language = "English",
volume = "275",
pages = "163--170",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-d-aspartate-induced aversive behavior. / Maeda, Yohko; Yamada, Kiyofumi; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: European Journal of Pharmacology, Vol. 275, No. 2, 06.03.1995, p. 163-170.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-d-aspartate-induced aversive behavior

AU - Maeda, Yohko

AU - Yamada, Kiyofumi

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

PY - 1995/3/6

Y1 - 1995/3/6

N2 - To elucidate the mechanism of antinociceptive effects of calcitonin, we investigated whether receptor antagonists for various neurotransmitter receptors alter the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice. Neither naloxone, an opioid receptor antagonist, phentolamine and benextramine, α-adrenoceptor antagonists, nor ritanserin, a 5-HT2A receptor antagonist, inhibited the calcitonin-induced anti-aversive effects. Pindolol and (-)-propranolol, non-selective antagonists of β-adrenoceptors and 5-HT1 receptors, 1-(2-methoxyphenyl)-4-[4-(2-phethalimido) butyl]-piperazine hydrobromide (NAN-190), a 5-HT1A receptor antagonist, 3-tropanyl-3,5-dichlorobenzoate (MDL72222) and metoclopramide, 5-HT3 receptor antagonists, significantly inhibited the calcitonin-induced anti-aversive effects. (-)-Bicuculline, a GABAA receptor antagonist, phaclofen and 5-aminovaleric acid, GABAB receptor antagonists, also attenuated the calcitonin-induced anti-aversive effects. These results suggest that β-adrenoceptor, 5-HT1A, 5-HT3, GABAA and GABAB receptors, but not α-adrenoceptor, opioid nor 5-HT2A receptors, are involved in the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice.

AB - To elucidate the mechanism of antinociceptive effects of calcitonin, we investigated whether receptor antagonists for various neurotransmitter receptors alter the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice. Neither naloxone, an opioid receptor antagonist, phentolamine and benextramine, α-adrenoceptor antagonists, nor ritanserin, a 5-HT2A receptor antagonist, inhibited the calcitonin-induced anti-aversive effects. Pindolol and (-)-propranolol, non-selective antagonists of β-adrenoceptors and 5-HT1 receptors, 1-(2-methoxyphenyl)-4-[4-(2-phethalimido) butyl]-piperazine hydrobromide (NAN-190), a 5-HT1A receptor antagonist, 3-tropanyl-3,5-dichlorobenzoate (MDL72222) and metoclopramide, 5-HT3 receptor antagonists, significantly inhibited the calcitonin-induced anti-aversive effects. (-)-Bicuculline, a GABAA receptor antagonist, phaclofen and 5-aminovaleric acid, GABAB receptor antagonists, also attenuated the calcitonin-induced anti-aversive effects. These results suggest that β-adrenoceptor, 5-HT1A, 5-HT3, GABAA and GABAB receptors, but not α-adrenoceptor, opioid nor 5-HT2A receptors, are involved in the inhibitory effect of calcitonin on intrathecally injected N-methyl-d-aspartate-induced aversive behavior in mice.

UR - http://www.scopus.com/inward/record.url?scp=0028930452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028930452&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(94)00764-X

DO - 10.1016/0014-2999(94)00764-X

M3 - Article

VL - 275

SP - 163

EP - 170

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -