Neuronal polarity: From extracellular signals to intracellular mechanisms

Nariko Arimura; Kozo Kaibuchi

doi:10.1038/nrn2056

Neuronal polarity: From extracellular signals to intracellular mechanisms

Nariko Arimura, Kozo Kaibuchi

Research output: Contribution to journal › Review article › peer-review

538 Citations (Scopus)

Abstract

After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally distinct compartments - axons and dendrites - within one cell. How do neurons develop their morphologically and molecularly distinct compartments? Recent studies have implicated several signalling pathways evoked by extracellular signals as having essential roles in a number of aspects of neuronal polarization.

Original language	English
Pages (from-to)	194-205
Number of pages	12
Journal	Nature Reviews Neuroscience
Volume	8
Issue number	3
DOIs	https://doi.org/10.1038/nrn2056
Publication status	Published - 03-2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1038/nrn2056

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title = "Neuronal polarity: From extracellular signals to intracellular mechanisms",

abstract = "After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally distinct compartments - axons and dendrites - within one cell. How do neurons develop their morphologically and molecularly distinct compartments? Recent studies have implicated several signalling pathways evoked by extracellular signals as having essential roles in a number of aspects of neuronal polarization.",

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AB - After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally distinct compartments - axons and dendrites - within one cell. How do neurons develop their morphologically and molecularly distinct compartments? Recent studies have implicated several signalling pathways evoked by extracellular signals as having essential roles in a number of aspects of neuronal polarization.

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Neuronal polarity: From extracellular signals to intracellular mechanisms

Abstract

All Science Journal Classification (ASJC) codes

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