Neuronal polarization

Tetsuya Takano, Chundi Xu, Yasuhiro Funahashi, Takashi Namba, Kozo Kaibuchi

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Neurons are highly polarized cells with structurally and functionally distinct processes called axons and dendrites. This polarization underlies the directional flow of information in the central nervous system, so the establishment and maintenance of neuronal polarization is crucial for correct development and function. Great progress in our understanding of how neurons establish their polarity has been made through the use of cultured hippocampal neurons, while recent technological advances have enabled in vivo analysis of axon specification and elongation. This short review and accompanying poster highlight recent advances in this fascinating field, with an emphasis on the signaling mechanisms underlying axon and dendrite specification in vitro and in vivo.

Original languageEnglish
Pages (from-to)2088-2093
Number of pages6
JournalDevelopment (Cambridge)
Volume142
Issue number12
DOIs
Publication statusPublished - 15-06-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

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