Neuropharmacological effects of sigma receptor ligands: Anxiolytic, anti-amnesic and neuroprotective effects

M. Amano, K. Yamada, K. Matsuno, T. Nabeshima

Research output: Contribution to journalReview article

7 Citations (Scopus)


There is evidence for the existence of two classes of sigma binding sites, termed 'site 1' and 'site 2', that are distinct from opioid and PCP receptors. Sigma receptor ligands may be useful in the treatment of schizophrenia, since they improve not only positive but also negative symptoms with little extrapyramidal side effects in animal models. In addition, recent experiments have demonstrated that sigma receptor ligands attenuate the motor suppression and colonic motor disturbances seen under menially stressful situations, stimulate the central cholinergic function thereby ameliorating impairment of learning and memory, and protect cerebral neurons against cerebral ischemic insult. The present review describes the neuropharmacological effects of sigma receptor ligands, especially anxiolytic (anti-stress) effects, ameliorating effects on impairment of learning and memory, and neuroprotective effects.

Original languageEnglish
Pages (from-to)73-84
Number of pages12
JournalJapanese Journal of Psychopharmacology
Issue number3
Publication statusPublished - 11-09-1996
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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