Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs

Eun Joo Shin, Jae Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau Shyong Hong, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalReview article

27 Citations (Scopus)


Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

Original languageEnglish
Pages (from-to)137-148
Number of pages12
JournalJournal of Pharmacological Sciences
Issue number2
Publication statusPublished - 24-06-2011
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Shin, E. J., Bach, J. H., Lee, S. Y., Kim, J. M., Lee, J., Hong, J. S., Nabeshima, T., & Kim, H. C. (2011). Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. Journal of Pharmacological Sciences, 116(2), 137-148.