Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs

Eun Joo Shin, Jae Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau Shyong Hong, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

Original languageEnglish
Pages (from-to)137-148
Number of pages12
JournalJournal of Pharmacological Sciences
Volume116
Issue number2
DOIs
Publication statusPublished - 24-06-2011

Fingerprint

Dextromethorphan
Neuroprotective Agents
Therapeutic Uses
Neurodegenerative Diseases
Central Nervous System
dimemorfan
norlevorphanol

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Shin, E. J., Bach, J. H., Lee, S. Y., Kim, J. M., Lee, J., Hong, J. S., ... Kim, H. C. (2011). Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. Journal of Pharmacological Sciences, 116(2), 137-148. https://doi.org/10.1254/jphs.11R02CR
Shin, Eun Joo ; Bach, Jae Hyung ; Lee, Sung Youl ; Kim, Jeong Min ; Lee, Jinhwa ; Hong, Jau Shyong ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. In: Journal of Pharmacological Sciences. 2011 ; Vol. 116, No. 2. pp. 137-148.
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Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. / Shin, Eun Joo; Bach, Jae Hyung; Lee, Sung Youl; Kim, Jeong Min; Lee, Jinhwa; Hong, Jau Shyong; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 116, No. 2, 24.06.2011, p. 137-148.

Research output: Contribution to journalReview article

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