Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats

Kiyofumi Yamada, Kazuyuki Fuji, Toshitaka Nabeshima, Tsutomu Kameyama

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalNeuroscience Letters
Volume118
Issue number1
DOIs
Publication statusPublished - 02-10-1990
Externally publishedYes

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Quinolinic Acid
Lateral Ventricles
Glutamate Decarboxylase
Choline O-Acetyltransferase
Hemicholinium 3
Dizocilpine Maleate
Neurodegenerative Diseases
Alzheimer Disease
Chronic Disease
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yamada, Kiyofumi ; Fuji, Kazuyuki ; Nabeshima, Toshitaka ; Kameyama, Tsutomu. / Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats. In: Neuroscience Letters. 1990 ; Vol. 118, No. 1. pp. 128-131.
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Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats. / Yamada, Kiyofumi; Fuji, Kazuyuki; Nabeshima, Toshitaka; Kameyama, Tsutomu.

In: Neuroscience Letters, Vol. 118, No. 1, 02.10.1990, p. 128-131.

Research output: Contribution to journalArticle

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