TY - JOUR
T1 - Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats
AU - Yamada, Kiyofumi
AU - Fuji, Kazuyuki
AU - Nabeshima, Toshitaka
AU - Kameyama, Tsutomu
N1 - Funding Information:
This work was supported in part by Otsuka Pharmaceutical Co., Ltd., Japan.
PY - 1990/10/2
Y1 - 1990/10/2
N2 - Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.
AB - Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.
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U2 - 10.1016/0304-3940(90)90265-B
DO - 10.1016/0304-3940(90)90265-B
M3 - Article
C2 - 2147984
AN - SCOPUS:0025092846
SN - 0304-3940
VL - 118
SP - 128
EP - 131
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -