Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats

Kiyofumi Yamada, Kazuyuki Fuji, Toshitaka Nabeshima, Tsutomu Kameyama

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Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 02-10-1990


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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