Abstract
Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.
| Original language | English |
|---|---|
| Pages (from-to) | 138-143 |
| Number of pages | 6 |
| Journal | European Neurology |
| Volume | 65 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-03-2011 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis. / Kizawa-Ueda, Madoka; Ueda, Akihiro; Kawamura, Naoki; Ishikawa, Tomomasa; Mutoh, Eri; Fukuda, Yu; Shiroki, Ryouichi; Hoshinaga, Kiyotaka; Ito, Shinji; Asakura, Kunihiko; Mutoh, Tatsuro.
In: European Neurology, Vol. 65, No. 3, 01.03.2011, p. 138-143.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis
AU - Kizawa-Ueda, Madoka
AU - Ueda, Akihiro
AU - Kawamura, Naoki
AU - Ishikawa, Tomomasa
AU - Mutoh, Eri
AU - Fukuda, Yu
AU - Shiroki, Ryouichi
AU - Hoshinaga, Kiyotaka
AU - Ito, Shinji
AU - Asakura, Kunihiko
AU - Mutoh, Tatsuro
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.
AB - Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.
UR - http://www.scopus.com/inward/record.url?scp=79952051087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952051087&partnerID=8YFLogxK
U2 - 10.1159/000324327
DO - 10.1159/000324327
M3 - Article
C2 - 21358203
AN - SCOPUS:79952051087
VL - 65
SP - 138
EP - 143
JO - European Neurology
JF - European Neurology
SN - 0014-3022
IS - 3
ER -