Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis

Madoka Kizawa-Ueda; Akihiro Ueda; Naoki Kawamura; Tomomasa Ishikawa; Eri Mutoh; Yu Fukuda; Ryouichi Shiroki; Kiyotaka Hoshinaga; Shinji Ito; Kunihiko Asakura; Tatsuro Mutoh

doi:10.1159/000324327

Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis

Madoka Kizawa-Ueda, Akihiro Ueda, Naoki Kawamura, Tomomasa Ishikawa, Eri Mutoh, Yu Fukuda, Ryouichi Shiroki, Kiyotaka Hoshinaga, Shinji Ito, Kunihiko Asakura, Tatsuro Mutoh

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.

Original language	English
Pages (from-to)	138-143
Number of pages	6
Journal	European Neurology
Volume	65
Issue number	3
DOIs	https://doi.org/10.1159/000324327
Publication status	Published - 01-03-2011

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

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title = "Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis",

abstract = "Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.",

author = "Madoka Kizawa-Ueda and Akihiro Ueda and Naoki Kawamura and Tomomasa Ishikawa and Eri Mutoh and Yu Fukuda and Ryouichi Shiroki and Kiyotaka Hoshinaga and Shinji Ito and Kunihiko Asakura and Tatsuro Mutoh",

year = "2011",

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doi = "10.1159/000324327",

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Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis. / Kizawa-Ueda, Madoka; Ueda, Akihiro; Kawamura, Naoki; Ishikawa, Tomomasa; Mutoh, Eri; Fukuda, Yu; Shiroki, Ryouichi; Hoshinaga, Kiyotaka; Ito, Shinji; Asakura, Kunihiko; Mutoh, Tatsuro.

In: European Neurology, Vol. 65, No. 3, 01.03.2011, p. 138-143.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis

AU - Kizawa-Ueda, Madoka

AU - Ueda, Akihiro

AU - Kawamura, Naoki

AU - Ishikawa, Tomomasa

AU - Mutoh, Eri

AU - Fukuda, Yu

AU - Shiroki, Ryouichi

AU - Hoshinaga, Kiyotaka

AU - Ito, Shinji

AU - Asakura, Kunihiko

AU - Mutoh, Tatsuro

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.

AB - Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.

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