Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis

Madoka Kizawa-Ueda, Akihiro Ueda, Naoki Kawamura, Tomomasa Ishikawa, Eri Mutoh, Yu Fukuda, Ryouichi Shiroki, Kiyotaka Hoshinaga, Shinji Ito, Kunihiko Asakura, Tatsuro Mutoh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalEuropean Neurology
Volume65
Issue number3
DOIs
Publication statusPublished - 01-03-2011

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Nerve Growth Factors
Encephalitis
Meningitis
Neurotrophin 3
Cerebrospinal Fluid
Nerve Growth Factor
Central Nervous System Infections
Meningoencephalitis
Brain-Derived Neurotrophic Factor
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kizawa-Ueda, M., Ueda, A., Kawamura, N., Ishikawa, T., Mutoh, E., Fukuda, Y., ... Mutoh, T. (2011). Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis. European Neurology, 65(3), 138-143. https://doi.org/10.1159/000324327
Kizawa-Ueda, Madoka ; Ueda, Akihiro ; Kawamura, Naoki ; Ishikawa, Tomomasa ; Mutoh, Eri ; Fukuda, Yu ; Shiroki, Ryouichi ; Hoshinaga, Kiyotaka ; Ito, Shinji ; Asakura, Kunihiko ; Mutoh, Tatsuro. / Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis. In: European Neurology. 2011 ; Vol. 65, No. 3. pp. 138-143.
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abstract = "Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.",
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Kizawa-Ueda, M, Ueda, A, Kawamura, N, Ishikawa, T, Mutoh, E, Fukuda, Y, Shiroki, R, Hoshinaga, K, Ito, S, Asakura, K & Mutoh, T 2011, 'Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis', European Neurology, vol. 65, no. 3, pp. 138-143. https://doi.org/10.1159/000324327

Neurotrophin levels in cerebrospinal fluid of adult patients with meningitis and encephalitis. / Kizawa-Ueda, Madoka; Ueda, Akihiro; Kawamura, Naoki; Ishikawa, Tomomasa; Mutoh, Eri; Fukuda, Yu; Shiroki, Ryouichi; Hoshinaga, Kiyotaka; Ito, Shinji; Asakura, Kunihiko; Mutoh, Tatsuro.

In: European Neurology, Vol. 65, No. 3, 01.03.2011, p. 138-143.

Research output: Contribution to journalArticle

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AU - Ueda, Akihiro

AU - Kawamura, Naoki

AU - Ishikawa, Tomomasa

AU - Mutoh, Eri

AU - Fukuda, Yu

AU - Shiroki, Ryouichi

AU - Hoshinaga, Kiyotaka

AU - Ito, Shinji

AU - Asakura, Kunihiko

AU - Mutoh, Tatsuro

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