Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma

Ei Ei Khin, Fumitaka Kikkawa, Kazuhiko Ino, Takahiro Suzuki, Kiyosumi Shibata, Hiroaki Kajiyama, Koji Tamakoshi, Shigehiko Mizutani

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19 Citations (Scopus)


This study investigated the immunohistochemical expression and localization of neutral endopeptidase (NEP) (CD10), which plays a functional role by degrading bioactive peptides, in ovarian tumors. In normal ovaries and benign cystadenomas, NEP was not detected in any epithelial or stromal cells. In borderline tumors, NEP was detected in the stromal cells in 6 of 7 serous tumors, but not in those from mucinous tumors. In ovarian carcinomas, NEP in the stromal cells was observed in 13 of 20 serous, 8 of 10 endometrioid, and 7 of 10 clear-cell adenocarcinomas. NEP was weakly detected in only 1 of 9 mucinous adenocarcinomas. The staining intensity of stromal NEP was decreased in grades 2 and 3 serous carcinomas compared with that in grade 1 serous carcinomas. In conclusion, NEP was specifically expressed in the stroma of borderline and malignant ovarian tumors, but not in adenomas. Furthermore, stromal NEP was downregulated as the histological grade advanced. These results suggest that NEP may play a role in the regulation of neoplastic transformation and tumor differentiation in epithelial ovarian carcinomas.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalInternational Journal of Gynecological Pathology
Issue number2
Publication statusPublished - 01-04-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology


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