TY - JOUR
T1 - New neurons follow the flow of cerebrospinal fluid in the adult brain
AU - Sawamoto, Kazunobu
AU - Wichterle, Hynek
AU - Gonzalez-Perez, Oscar
AU - Cholfin, Jeremy A.
AU - Yamada, Masayuki
AU - Spassky, Nathalie
AU - Murcia, Noel S.
AU - Garcia-Verdugo, Jose Manuel
AU - Marin, Oscar
AU - Rubenstein, John L.R.
AU - Tessier-Lavigne, Marc
AU - Okano, Hideyuki
AU - Alvarez-Buylla, Arturo
PY - 2006/2/3
Y1 - 2006/2/3
N2 - In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
AB - In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
UR - http://www.scopus.com/inward/record.url?scp=31944434903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=31944434903&partnerID=8YFLogxK
U2 - 10.1126/science.1119133
DO - 10.1126/science.1119133
M3 - Article
C2 - 16410488
AN - SCOPUS:31944434903
SN - 0036-8075
VL - 311
SP - 629
EP - 632
JO - Science
JF - Science
IS - 5761
ER -