New neurons follow the flow of cerebrospinal fluid in the adult brain

Kazunobu Sawamoto, Hynek Wichterle, Oscar Gonzalez-Perez, Jeremy A. Cholfin, Masayuki Yamada, Nathalie Spassky, Noel S. Murcia, Jose Manuel Garcia-Verdugo, Oscar Marin, John L.R. Rubenstein, Marc Tessier-Lavigne, Hideyuki Okano, Arturo Alvarez-Buylla

Research output: Contribution to journalArticle

499 Citations (Scopus)

Abstract

In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalScience
Volume311
Issue number5761
DOIs
Publication statusPublished - 03-02-2006

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Cerebrospinal Fluid
Lateral Ventricles
Neurons
Brain
Cilia
Olfactory Bulb
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • General

Cite this

Sawamoto, K., Wichterle, H., Gonzalez-Perez, O., Cholfin, J. A., Yamada, M., Spassky, N., ... Alvarez-Buylla, A. (2006). New neurons follow the flow of cerebrospinal fluid in the adult brain. Science, 311(5761), 629-632. https://doi.org/10.1126/science.1119133
Sawamoto, Kazunobu ; Wichterle, Hynek ; Gonzalez-Perez, Oscar ; Cholfin, Jeremy A. ; Yamada, Masayuki ; Spassky, Nathalie ; Murcia, Noel S. ; Garcia-Verdugo, Jose Manuel ; Marin, Oscar ; Rubenstein, John L.R. ; Tessier-Lavigne, Marc ; Okano, Hideyuki ; Alvarez-Buylla, Arturo. / New neurons follow the flow of cerebrospinal fluid in the adult brain. In: Science. 2006 ; Vol. 311, No. 5761. pp. 629-632.
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abstract = "In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.",
author = "Kazunobu Sawamoto and Hynek Wichterle and Oscar Gonzalez-Perez and Cholfin, {Jeremy A.} and Masayuki Yamada and Nathalie Spassky and Murcia, {Noel S.} and Garcia-Verdugo, {Jose Manuel} and Oscar Marin and Rubenstein, {John L.R.} and Marc Tessier-Lavigne and Hideyuki Okano and Arturo Alvarez-Buylla",
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Sawamoto, K, Wichterle, H, Gonzalez-Perez, O, Cholfin, JA, Yamada, M, Spassky, N, Murcia, NS, Garcia-Verdugo, JM, Marin, O, Rubenstein, JLR, Tessier-Lavigne, M, Okano, H & Alvarez-Buylla, A 2006, 'New neurons follow the flow of cerebrospinal fluid in the adult brain', Science, vol. 311, no. 5761, pp. 629-632. https://doi.org/10.1126/science.1119133

New neurons follow the flow of cerebrospinal fluid in the adult brain. / Sawamoto, Kazunobu; Wichterle, Hynek; Gonzalez-Perez, Oscar; Cholfin, Jeremy A.; Yamada, Masayuki; Spassky, Nathalie; Murcia, Noel S.; Garcia-Verdugo, Jose Manuel; Marin, Oscar; Rubenstein, John L.R.; Tessier-Lavigne, Marc; Okano, Hideyuki; Alvarez-Buylla, Arturo.

In: Science, Vol. 311, No. 5761, 03.02.2006, p. 629-632.

Research output: Contribution to journalArticle

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Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006 Feb 3;311(5761):629-632. https://doi.org/10.1126/science.1119133