New Prognostic Indicator is Useful for Predicting the Survival of Patients with Unresectable Advanced Colorectal Cancer

Masahide Ikeguchi, Keigo Ashida, Hiroaki Saito

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

BACKGROUND/AIMS: Complete resection of tumors is possible after heavy chemotherapy in a few patients with unresectable colorectal cancer (UCRC). This study evaluated the ability of new prognostic score to identify such patients.

METHODOLOGY: Four peripheral blood markers were evaluated in 50 patients diagnosed with UCRC at the time of patients' first visit to the hospital: C-reactive protein (CRP), albumin (ALB), neutrophil/lymphocyte ratio (NLR), and carcinoembryonic antigen (CEA). Each was scored +1 or 0 for that marker. For example, when patient shows CRP ≥ 1.0 mg/dL, ALB 3.5 g/dL, NLR ≥ 5, and CEA ≥ 10 ng/mL, his score is +4. Thus, patients' scores could range from 0 to +4.

RESULTS: The median survival time (MST) of the 15 patients with scores 0 and +1 was longer than that of the 35 with scores +2, +3, and +4 (35 vs. 6 months, P < 0.001). R0 operation after treatment was performed in 2 patients (4%) with score 0 and +1.

CONCLUSION: Our prognostic score is useful in selecting patients with UCRC who will survive.

Original languageEnglish
Pages (from-to)859-862
Number of pages4
JournalHepato-gastroenterology
Volume62
Issue number140
Publication statusPublished - 01-06-2015

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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