TY - JOUR
T1 - New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study
AU - Nakajima, Masahiro
AU - Takahashi, Atsushi
AU - Kou, Ikuyo
AU - Rodriguez-Fontenla, Cristina
AU - Gomez-Reino, Juan J.
AU - Furuichi, Tatsuya
AU - Dai, Jin
AU - Sudo, Akihiro
AU - Uchida, Atsumasa
AU - Fukui, Naoshi
AU - Kubo, Michiaki
AU - Kamatani, Naoyuki
AU - Tsunoda, Tatsuhiko
AU - Malizos, Konstantinos N.
AU - Tsezou, Aspasia
AU - Gonzalez, Antonio
AU - Nakamura, Yusuke
AU - Ikegawa, Shiro
PY - 2010
Y1 - 2010
N2 - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
AB - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
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U2 - 10.1371/journal.pone.0009723
DO - 10.1371/journal.pone.0009723
M3 - Article
C2 - 20305777
AN - SCOPUS:78149408549
SN - 1932-6203
VL - 5
JO - PloS one
JF - PloS one
IS - 3
M1 - e9723
ER -