New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

Masahiro Nakajima; Atsushi Takahashi; Ikuyo Kou; Cristina Rodriguez-Fontenla; Juan J. Gomez-Reino; Tatsuya Furuichi; Jin Dai; Akihiro Sudo; Atsumasa Uchida; Naoshi Fukui; Michiaki Kubo; Naoyuki Kamatani; Tatsuhiko Tsunoda; Konstantinos N. Malizos; Aspasia Tsezou; Antonio Gonzalez; Yusuke Nakamura; Shiro Ikegawa

doi:10.1371/journal.pone.0009723

New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

Masahiro Nakajima
, Atsushi Takahashi
, Ikuyo Kou
, Cristina Rodriguez-Fontenla
, Juan J. Gomez-Reino
, Tatsuya Furuichi
, Jin Dai
, Akihiro Sudo
, Atsumasa Uchida
, Naoshi Fukui
, Michiaki Kubo
, Naoyuki Kamatani
, Tatsuhiko Tsunoda
, Konstantinos N. Malizos
, Aspasia Tsezou
, Antonio Gonzalez
, Yusuke Nakamura
, Shiro Ikegawa

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10^-8 for rs7775228 and 6.73×10^-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

Original language	English
Article number	e9723
Journal	PloS one
Volume	5
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0009723
Publication status	Published - 2010
Externally published	Yes

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Nakajima, M., Takahashi, A., Kou, I., Rodriguez-Fontenla, C., Gomez-Reino, J. J., Furuichi, T., Dai, J., Sudo, A., Uchida, A., Fukui, N., Kubo, M., Kamatani, N., Tsunoda, T., Malizos, K. N., Tsezou, A., Gonzalez, A., Nakamura, Y., & Ikegawa, S. (2010). New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study. PloS one, 5(3), Article e9723. https://doi.org/10.1371/journal.pone.0009723

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title = "New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study",

abstract = "Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of \textasciitilde{}4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.",

author = "Masahiro Nakajima and Atsushi Takahashi and Ikuyo Kou and Cristina Rodriguez-Fontenla and Gomez-Reino, \{Juan J.\} and Tatsuya Furuichi and Jin Dai and Akihiro Sudo and Atsumasa Uchida and Naoshi Fukui and Michiaki Kubo and Naoyuki Kamatani and Tatsuhiko Tsunoda and Malizos, \{Konstantinos N.\} and Aspasia Tsezou and Antonio Gonzalez and Yusuke Nakamura and Shiro Ikegawa",

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doi = "10.1371/journal.pone.0009723",

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Nakajima, M, Takahashi, A, Kou, I, Rodriguez-Fontenla, C, Gomez-Reino, JJ, Furuichi, T, Dai, J, Sudo, A, Uchida, A, Fukui, N, Kubo, M, Kamatani, N, Tsunoda, T, Malizos, KN, Tsezou, A, Gonzalez, A, Nakamura, Y & Ikegawa, S 2010, 'New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study', PloS one, vol. 5, no. 3, e9723. https://doi.org/10.1371/journal.pone.0009723

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T1 - New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

AU - Nakajima, Masahiro

AU - Takahashi, Atsushi

AU - Kou, Ikuyo

AU - Rodriguez-Fontenla, Cristina

AU - Gomez-Reino, Juan J.

AU - Furuichi, Tatsuya

AU - Dai, Jin

AU - Sudo, Akihiro

AU - Uchida, Atsumasa

AU - Fukui, Naoshi

AU - Kubo, Michiaki

AU - Kamatani, Naoyuki

AU - Tsunoda, Tatsuhiko

AU - Malizos, Konstantinos N.

AU - Tsezou, Aspasia

AU - Gonzalez, Antonio

AU - Nakamura, Yusuke

AU - Ikegawa, Shiro

PY - 2010

Y1 - 2010

N2 - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

AB - Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10-8 for rs7775228 and 6.73×10-8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

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AN - SCOPUS:78149408549

SN - 1932-6203

VL - 5

JO - PloS one

JF - PloS one

IS - 3

M1 - e9723

ER -

New sequence variants in HLA Class II/III region associated with susceptibility to knee Osteoarthritis identified by genome-wide association study

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