TY - JOUR
T1 - NGF Level Is Not Decreased in the Serum, Brain-Spinal Fluid, Hippocampus, or Parietal Cortex of Individuals with Alzheimer′s Disease
AU - Murase, K.
AU - Nabeshima, T.
AU - Robitaille, Y.
AU - Quirion, R.
AU - Ogawa, M.
AU - Hayashi, K.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 1993/5/28
Y1 - 1993/5/28
N2 - Although the cause of Alzheimers disease (AD) is unknown, nerve growth factor (NGF) has gained attention as a therapeutic agent for the disease. Because NGF maintains the magnocellular cholinergic neurons that are damaged in AD, research interests have been focused on the change in NGF level in patients with AD. This is the first reported study in which human NGF levels were accurately measured and compared between normal and AD samples. We measured NGF levels using enzyme immunoassay (EIA) system for human NGF and found no difference in NGF level in serum, brain-spinal fluid, or brain (hippocampus and parietal cortex) obtained from normal people and patients with AD. These results suggest that a decrease in the NGF level is not a causative factor of AD.
AB - Although the cause of Alzheimers disease (AD) is unknown, nerve growth factor (NGF) has gained attention as a therapeutic agent for the disease. Because NGF maintains the magnocellular cholinergic neurons that are damaged in AD, research interests have been focused on the change in NGF level in patients with AD. This is the first reported study in which human NGF levels were accurately measured and compared between normal and AD samples. We measured NGF levels using enzyme immunoassay (EIA) system for human NGF and found no difference in NGF level in serum, brain-spinal fluid, or brain (hippocampus and parietal cortex) obtained from normal people and patients with AD. These results suggest that a decrease in the NGF level is not a causative factor of AD.
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U2 - 10.1006/bbrc.1993.1609
DO - 10.1006/bbrc.1993.1609
M3 - Article
C2 - 8503908
AN - SCOPUS:0027276502
SN - 0006-291X
VL - 193
SP - 198
EP - 203
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -