TY - JOUR
T1 - Nicotine ameliorates impairment of working memory in methamphetamine-treated rats
AU - Mizoguchi, Hiroyuki
AU - Ibi, Daisuke
AU - Takase, Fumiaki
AU - Nagai, Taku
AU - Kamei, Hiroyuki
AU - Toth, Erika
AU - Sato, Jun
AU - Takuma, Kazuhiro
AU - Yamada, Kiyofumi
N1 - Funding Information:
This study was supported in part by grants-in-aid for Scientific Research (nos. 19390062 , 21790068 and 22390046 ) from the Japan Society for the Promotion of Science , and by a grant from the Smoking Research Foundation, Japan , a grant for the global COE program from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a grant from the Academic Frontier Project for Private Universities, matching fund subsidy from MEXT, 2007–2011, a grant for Research on the Risk of Chemical Substances, Health and Labour Science Research Grants supported by the Ministry of Health, Labour and Welfare , and a grant from the Regional Joint Research Program supported by grants to Private Universities to Cover Current Expenses from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) .
PY - 2011/6/20
Y1 - 2011/6/20
N2 - Nicotine is hypothesized to have therapeutic effects on attentional and cognitive abnormalities in psychosis. In this study, we investigated the effect of nicotine on impaired spatial working memory in repeated methamphetamine (METH)-treated rats. Rats were administered METH (4. mg/kg, s.c.) once a day for 7 days, and their working memory was assessed with a delayed spatial win-shift task in a radial arm maze. The task consisted of two phases, a training phase and a test phase, separated by a delay. Control animals showed impaired performance in the test phase when the delay time was increased to 120. min or longer, while METH-treated rats showed impaired performance with a shorter delay time of 90. min. Memory impairment in METH-treated rats persisted for at least 14 days after drug withdrawal. METH-induced impairment of working memory was reversed by nicotine (0.3. mg/kg, p.o., for 7 days), but the effect was diminished 7 days after the withdrawal. In control rats, nicotine decreased the number of working memory errors in the test with delay time of 120. min when administered before the training phase. Neither post-training nor pre-test administration of nicotine had any effect on working memory. These findings suggest that nicotine may have some protective effect against the impairment of working memory.
AB - Nicotine is hypothesized to have therapeutic effects on attentional and cognitive abnormalities in psychosis. In this study, we investigated the effect of nicotine on impaired spatial working memory in repeated methamphetamine (METH)-treated rats. Rats were administered METH (4. mg/kg, s.c.) once a day for 7 days, and their working memory was assessed with a delayed spatial win-shift task in a radial arm maze. The task consisted of two phases, a training phase and a test phase, separated by a delay. Control animals showed impaired performance in the test phase when the delay time was increased to 120. min or longer, while METH-treated rats showed impaired performance with a shorter delay time of 90. min. Memory impairment in METH-treated rats persisted for at least 14 days after drug withdrawal. METH-induced impairment of working memory was reversed by nicotine (0.3. mg/kg, p.o., for 7 days), but the effect was diminished 7 days after the withdrawal. In control rats, nicotine decreased the number of working memory errors in the test with delay time of 120. min when administered before the training phase. Neither post-training nor pre-test administration of nicotine had any effect on working memory. These findings suggest that nicotine may have some protective effect against the impairment of working memory.
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U2 - 10.1016/j.bbr.2011.01.036
DO - 10.1016/j.bbr.2011.01.036
M3 - Article
C2 - 21277906
AN - SCOPUS:79951953399
VL - 220
SP - 159
EP - 163
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 1
ER -