Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells

Naohiro Ichino, Hiroshi Ishiguro, Koji Yamada, Kazuhiro Nishii, Hirohide Sawada, Toshiharu Nagatsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The influence of nicotine on the expression of Fos family proteins, which specifically formed complexes with the AP-1 sequence, was assessed. mRNA for c-Fos, c-jun and jun-B were up-regulated at 0.5 h after nicotine treatment, elevated c-Fos also being apparent after withdrawal. Although nicotine failed to up-regulate the mRNA level of the fra-1 gene, the Fra-1 protein was highly expressed after both treatment and withdrawal. These results indicate that nicotine treatment may affect the transcriptional activity of many genes through c-Fos and c-Jun protein expression in neural cells, and that Fra-1 protein may make a contribution. These changes in immediately early genes (IEGs) may be associated with nicotine withdrawal symptoms.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalNeuroscience Research
Volume35
Issue number1
DOIs
Publication statusPublished - 01-10-1999

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Pheochromocytoma
Nicotine
Up-Regulation
Proto-Oncogene Proteins c-jun
fos Genes
Substance Withdrawal Syndrome
Messenger RNA
Transcription Factor AP-1
Genes
Proteins
fos-related antigen 1

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ichino, Naohiro ; Ishiguro, Hiroshi ; Yamada, Koji ; Nishii, Kazuhiro ; Sawada, Hirohide ; Nagatsu, Toshiharu. / Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells. In: Neuroscience Research. 1999 ; Vol. 35, No. 1. pp. 63-69.
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Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells. / Ichino, Naohiro; Ishiguro, Hiroshi; Yamada, Koji; Nishii, Kazuhiro; Sawada, Hirohide; Nagatsu, Toshiharu.

In: Neuroscience Research, Vol. 35, No. 1, 01.10.1999, p. 63-69.

Research output: Contribution to journalArticle

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