No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis

Tomomitsu Tahara, Tomiyasu Arisawa, Hiroshi Fujita, Yoshio Kamiya, Mitsuo Nagasaka, Masami Iwata, Fangyu Wang, Tomoyuki Shibata, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Kazuya Takahama, Makoto Watanabe, Hiroshi Nakano, Ichiro Hirata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: Reactive oxygen species has been implicated in the development of ulcerative colitis (UC). NADPH oxidase, a major source of superoxide generation play a critical role in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of UC in a Japanese population. Methodology: 123 UC patients and 459 healthy control (HC) subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the HC group, the p22 PHOX genotype distribution was 379C/C (821.6%), 79C/T (17.2%), and 5T/T (1.2%). Meanwhile, the p22 PHOX geno type distribution in UC group was 96C/C (78.0%), 26C/T (21.1%), and 1T/T (0.9%). No significant difference of the p22 PHOX genotype distribution was observed between HC and UC groups. (C/C us. T/T; OR=0.80, 95%CI=0.09-6.84, C/C, vs. C/T, OR=1.37, 95%CI=0.82-2.18, T/T vs. others; OR=0.74, 95%CI =0.09-6.43). No association was also found between p22PHOX gene polymorphism and different clinicopathological features of UC such as gender, age, age of onset, clinical type, extension of colitis and response to treatment. Conclusions: It Appears that the C242T polymorsphism of p22 PHOX is not associated with the incidence of gastric cancer in the Japanese population.

Original languageEnglish
Pages (from-to)1573-1577
Number of pages5
JournalHepato-gastroenterology
Volume55
Issue number86-87
Publication statusPublished - 01-09-2008

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NADPH Oxidase
Ulcerative Colitis
Genotype
Pylorus
Colitis
Age of Onset
Superoxides
Restriction Fragment Length Polymorphisms
Population
Stomach Neoplasms
Reactive Oxygen Species
Stomach
Healthy Volunteers
Inflammation
Polymerase Chain Reaction
Control Groups
Incidence
Genes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tahara, T., Arisawa, T., Fujita, H., Kamiya, Y., Nagasaka, M., Iwata, M., ... Hirata, I. (2008). No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis. Hepato-gastroenterology, 55(86-87), 1573-1577.
Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Fujita, Hiroshi ; Kamiya, Yoshio ; Nagasaka, Mitsuo ; Iwata, Masami ; Wang, Fangyu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Okubo, Masaaki ; Takahama, Kazuya ; Watanabe, Makoto ; Nakano, Hiroshi ; Hirata, Ichiro. / No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis. In: Hepato-gastroenterology. 2008 ; Vol. 55, No. 86-87. pp. 1573-1577.
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title = "No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis",
abstract = "Background/Aims: Reactive oxygen species has been implicated in the development of ulcerative colitis (UC). NADPH oxidase, a major source of superoxide generation play a critical role in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of UC in a Japanese population. Methodology: 123 UC patients and 459 healthy control (HC) subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the HC group, the p22 PHOX genotype distribution was 379C/C (821.6{\%}), 79C/T (17.2{\%}), and 5T/T (1.2{\%}). Meanwhile, the p22 PHOX geno type distribution in UC group was 96C/C (78.0{\%}), 26C/T (21.1{\%}), and 1T/T (0.9{\%}). No significant difference of the p22 PHOX genotype distribution was observed between HC and UC groups. (C/C us. T/T; OR=0.80, 95{\%}CI=0.09-6.84, C/C, vs. C/T, OR=1.37, 95{\%}CI=0.82-2.18, T/T vs. others; OR=0.74, 95{\%}CI =0.09-6.43). No association was also found between p22PHOX gene polymorphism and different clinicopathological features of UC such as gender, age, age of onset, clinical type, extension of colitis and response to treatment. Conclusions: It Appears that the C242T polymorsphism of p22 PHOX is not associated with the incidence of gastric cancer in the Japanese population.",
author = "Tomomitsu Tahara and Tomiyasu Arisawa and Hiroshi Fujita and Yoshio Kamiya and Mitsuo Nagasaka and Masami Iwata and Fangyu Wang and Tomoyuki Shibata and Masakatsu Nakamura and Daisuke Yoshioka and Masaaki Okubo and Kazuya Takahama and Makoto Watanabe and Hiroshi Nakano and Ichiro Hirata",
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Tahara, T, Arisawa, T, Fujita, H, Kamiya, Y, Nagasaka, M, Iwata, M, Wang, F, Shibata, T, Nakamura, M, Yoshioka, D, Okubo, M, Takahama, K, Watanabe, M, Nakano, H & Hirata, I 2008, 'No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis', Hepato-gastroenterology, vol. 55, no. 86-87, pp. 1573-1577.

No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Fujita, Hiroshi; Kamiya, Yoshio; Nagasaka, Mitsuo; Iwata, Masami; Wang, Fangyu; Shibata, Tomoyuki; Nakamura, Masakatsu; Yoshioka, Daisuke; Okubo, Masaaki; Takahama, Kazuya; Watanabe, Makoto; Nakano, Hiroshi; Hirata, Ichiro.

In: Hepato-gastroenterology, Vol. 55, No. 86-87, 01.09.2008, p. 1573-1577.

Research output: Contribution to journalArticle

TY - JOUR

T1 - No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Fujita, Hiroshi

AU - Kamiya, Yoshio

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Wang, Fangyu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Background/Aims: Reactive oxygen species has been implicated in the development of ulcerative colitis (UC). NADPH oxidase, a major source of superoxide generation play a critical role in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of UC in a Japanese population. Methodology: 123 UC patients and 459 healthy control (HC) subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the HC group, the p22 PHOX genotype distribution was 379C/C (821.6%), 79C/T (17.2%), and 5T/T (1.2%). Meanwhile, the p22 PHOX geno type distribution in UC group was 96C/C (78.0%), 26C/T (21.1%), and 1T/T (0.9%). No significant difference of the p22 PHOX genotype distribution was observed between HC and UC groups. (C/C us. T/T; OR=0.80, 95%CI=0.09-6.84, C/C, vs. C/T, OR=1.37, 95%CI=0.82-2.18, T/T vs. others; OR=0.74, 95%CI =0.09-6.43). No association was also found between p22PHOX gene polymorphism and different clinicopathological features of UC such as gender, age, age of onset, clinical type, extension of colitis and response to treatment. Conclusions: It Appears that the C242T polymorsphism of p22 PHOX is not associated with the incidence of gastric cancer in the Japanese population.

AB - Background/Aims: Reactive oxygen species has been implicated in the development of ulcerative colitis (UC). NADPH oxidase, a major source of superoxide generation play a critical role in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of UC in a Japanese population. Methodology: 123 UC patients and 459 healthy control (HC) subjects participated in this study. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: In the HC group, the p22 PHOX genotype distribution was 379C/C (821.6%), 79C/T (17.2%), and 5T/T (1.2%). Meanwhile, the p22 PHOX geno type distribution in UC group was 96C/C (78.0%), 26C/T (21.1%), and 1T/T (0.9%). No significant difference of the p22 PHOX genotype distribution was observed between HC and UC groups. (C/C us. T/T; OR=0.80, 95%CI=0.09-6.84, C/C, vs. C/T, OR=1.37, 95%CI=0.82-2.18, T/T vs. others; OR=0.74, 95%CI =0.09-6.43). No association was also found between p22PHOX gene polymorphism and different clinicopathological features of UC such as gender, age, age of onset, clinical type, extension of colitis and response to treatment. Conclusions: It Appears that the C242T polymorsphism of p22 PHOX is not associated with the incidence of gastric cancer in the Japanese population.

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Tahara T, Arisawa T, Fujita H, Kamiya Y, Nagasaka M, Iwata M et al. No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis. Hepato-gastroenterology. 2008 Sep 1;55(86-87):1573-1577.