No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients

Atsuko Ikenouchi-Sugita, Reiji Yoshimura, Taro Kishi, Wakako Umene-Nakano, Hikaru Hori, Asuka Katsuki, Kazuyoshi Saito, Nakao Iwata, Yoshiya Tanaka, Jun Nakamura

Research output: Contribution to journalArticle

Abstract

Background Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of psychiatric symptoms in patients with systemic lupus erythematosus (SLE). Objectives We hypothesized that the polymorphism of BDNF Val66Met is associated with the emergence of psychiatric symptoms (PS) and serum BDNF levels in SLE patients. To examine the hypothesis, we compared the BDNF Val66Met polymorphism and serum BDNF levels in patients with SLE with or without PS. Methods Psychiatric symptoms were assessed in 54 patients with SLE. PS were evaluated using the Brief Psychiatric Rating Scale. Genotyping was carried out using a 54-nuclease assay. Serum BDNF levels were measured by using enzyme-linked immunosorbent assay. Results The presence of the Met allele was not significantly associated with the presence of PS or with serum BDNF levels in patients with SLE. Conclusion Our data do not support the common variant Val66Met of the BDNF gene as an etiologic factor in the various forms of PS and serum BDNF levels in SLE.

Original languageEnglish
Pages (from-to)348-351
Number of pages4
JournalHuman Psychopharmacology
Volume26
Issue number4-5
DOIs
Publication statusPublished - 01-06-2011

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Brain-Derived Neurotrophic Factor
Systemic Lupus Erythematosus
Psychiatry
Serum
Neurotransmitter Agents
Brief Psychiatric Rating Scale
Neuronal Plasticity
Enzyme-Linked Immunosorbent Assay
Alleles

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Ikenouchi-Sugita, A., Yoshimura, R., Kishi, T., Umene-Nakano, W., Hori, H., Katsuki, A., ... Nakamura, J. (2011). No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients. Human Psychopharmacology, 26(4-5), 348-351. https://doi.org/10.1002/hup.1203
Ikenouchi-Sugita, Atsuko ; Yoshimura, Reiji ; Kishi, Taro ; Umene-Nakano, Wakako ; Hori, Hikaru ; Katsuki, Asuka ; Saito, Kazuyoshi ; Iwata, Nakao ; Tanaka, Yoshiya ; Nakamura, Jun. / No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients. In: Human Psychopharmacology. 2011 ; Vol. 26, No. 4-5. pp. 348-351.
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Ikenouchi-Sugita, A, Yoshimura, R, Kishi, T, Umene-Nakano, W, Hori, H, Katsuki, A, Saito, K, Iwata, N, Tanaka, Y & Nakamura, J 2011, 'No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients', Human Psychopharmacology, vol. 26, no. 4-5, pp. 348-351. https://doi.org/10.1002/hup.1203

No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients. / Ikenouchi-Sugita, Atsuko; Yoshimura, Reiji; Kishi, Taro; Umene-Nakano, Wakako; Hori, Hikaru; Katsuki, Asuka; Saito, Kazuyoshi; Iwata, Nakao; Tanaka, Yoshiya; Nakamura, Jun.

In: Human Psychopharmacology, Vol. 26, No. 4-5, 01.06.2011, p. 348-351.

Research output: Contribution to journalArticle

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T1 - No association between BDNF Val66Met polymorphism and emergence of psychiatric symptoms in systemic lupus erythematosus patients

AU - Ikenouchi-Sugita, Atsuko

AU - Yoshimura, Reiji

AU - Kishi, Taro

AU - Umene-Nakano, Wakako

AU - Hori, Hikaru

AU - Katsuki, Asuka

AU - Saito, Kazuyoshi

AU - Iwata, Nakao

AU - Tanaka, Yoshiya

AU - Nakamura, Jun

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Background Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of psychiatric symptoms in patients with systemic lupus erythematosus (SLE). Objectives We hypothesized that the polymorphism of BDNF Val66Met is associated with the emergence of psychiatric symptoms (PS) and serum BDNF levels in SLE patients. To examine the hypothesis, we compared the BDNF Val66Met polymorphism and serum BDNF levels in patients with SLE with or without PS. Methods Psychiatric symptoms were assessed in 54 patients with SLE. PS were evaluated using the Brief Psychiatric Rating Scale. Genotyping was carried out using a 54-nuclease assay. Serum BDNF levels were measured by using enzyme-linked immunosorbent assay. Results The presence of the Met allele was not significantly associated with the presence of PS or with serum BDNF levels in patients with SLE. Conclusion Our data do not support the common variant Val66Met of the BDNF gene as an etiologic factor in the various forms of PS and serum BDNF levels in SLE.

AB - Background Brain-derived neurotrophic factor (BDNF) plays an important role in the regulation of synaptic plasticity and neurotransmitter release across multiple neurotransmitter systems. Recent studies have suggested that BDNF plays a role in the pathogenesis of psychiatric symptoms in patients with systemic lupus erythematosus (SLE). Objectives We hypothesized that the polymorphism of BDNF Val66Met is associated with the emergence of psychiatric symptoms (PS) and serum BDNF levels in SLE patients. To examine the hypothesis, we compared the BDNF Val66Met polymorphism and serum BDNF levels in patients with SLE with or without PS. Methods Psychiatric symptoms were assessed in 54 patients with SLE. PS were evaluated using the Brief Psychiatric Rating Scale. Genotyping was carried out using a 54-nuclease assay. Serum BDNF levels were measured by using enzyme-linked immunosorbent assay. Results The presence of the Met allele was not significantly associated with the presence of PS or with serum BDNF levels in patients with SLE. Conclusion Our data do not support the common variant Val66Met of the BDNF gene as an etiologic factor in the various forms of PS and serum BDNF levels in SLE.

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