No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Tatsuyo Suzuki, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Altered dopamine D2 receptor (D2R) is hypothesized to be a susceptibility factor for major psychosis. Recent studies showed that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in D2R signaling. We conducted a genetic association analysis between Par-4 gene (PAWR) and schizophrenia and mood disorders in a Japanese population (schizophrenia: 556 cases, bipolar disorder (BP): 150 cases, major depressive disorder (MDD): 312 cases and 466 controls). Applying the recommended 'gene-based' association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant association was obtained found with schizophrenia or MDD or BP. We found a significant association of one tagging SNP with BP in a genotype-wise analysis (P = 0.0396); however, this might be resulted from type I error due to multiple testing (P = 0.158 after SNPSpD correction). Considering the size of our sample and strategy, our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population.

Original languageEnglish
Pages (from-to)531-534
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number4
DOIs
Publication statusPublished - 05-06-2008

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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