No association between the Bcl2-interacting killer (BIK) gene and schizophrenia

Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, Hidenaga Yamamori, Hiroaki Hori, Osamu Saitoh, Masahiko Tatsumi, Masatoshi Takeda, Nakao Iwata, Norio Ozaki, Kunitoshi Kamijima, Hiroshi Kunugi

Research output: Contribution to journalArticle

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Abstract

The Bcl2-interacting killer (BIK) gene interacts with cellular and viral survival-promoting proteins, such as Bcl-2, to enhance apoptosis. The BIK protein promotes cell death in a manner analogous to Bcl-2-related death-promoting proteins, Bax and Bak. There have been lower Bcl-2 levels and increased Bax/Bcl-2 ratio in the temporal cortex of patients with schizophrenia compared with those in controls. Because the death-promoting activity of BIK was suppressed in the presence of the cellular and viral survival-promoting proteins, the BIK protein is suggested as a likely target for antiapoptotic proteins. The purpose of this study is to investigate the association between genetic variants in the BIK gene and schizophrenia in a large Japanese population (1181 patients with schizophrenia and 1243 healthy controls). We found nominal evidence for association of alleles, rs926328 (χ2 = 4.44, p = 0.035, odds ratio = 1.13) and rs2235316 (χ2 = 4.41, p = 0.036, odds ratio = 1.13), with schizophrenia. However, these associations were no longer positive after correction for multiple testing (rs926328: corrected p = 0.105, rs2235316: corrected p = 0.108). We conclude that BIK might not play a major role in the susceptibility of schizophrenia in Japanese population.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalNeuroscience Letters
Volume463
Issue number1
DOIs
Publication statusPublished - 29-09-2009

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Schizophrenia
Genes
Proteins
Odds Ratio
bcl-2-Associated X Protein
Survival
Temporal Lobe
Population
Cell Death
Alleles
Apoptosis

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ohi, K., Hashimoto, R., Yasuda, Y., Yamamori, H., Hori, H., Saitoh, O., ... Kunugi, H. (2009). No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neuroscience Letters, 463(1), 60-63. https://doi.org/10.1016/j.neulet.2009.07.063
Ohi, Kazutaka ; Hashimoto, Ryota ; Yasuda, Yuka ; Yamamori, Hidenaga ; Hori, Hiroaki ; Saitoh, Osamu ; Tatsumi, Masahiko ; Takeda, Masatoshi ; Iwata, Nakao ; Ozaki, Norio ; Kamijima, Kunitoshi ; Kunugi, Hiroshi. / No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. In: Neuroscience Letters. 2009 ; Vol. 463, No. 1. pp. 60-63.
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abstract = "The Bcl2-interacting killer (BIK) gene interacts with cellular and viral survival-promoting proteins, such as Bcl-2, to enhance apoptosis. The BIK protein promotes cell death in a manner analogous to Bcl-2-related death-promoting proteins, Bax and Bak. There have been lower Bcl-2 levels and increased Bax/Bcl-2 ratio in the temporal cortex of patients with schizophrenia compared with those in controls. Because the death-promoting activity of BIK was suppressed in the presence of the cellular and viral survival-promoting proteins, the BIK protein is suggested as a likely target for antiapoptotic proteins. The purpose of this study is to investigate the association between genetic variants in the BIK gene and schizophrenia in a large Japanese population (1181 patients with schizophrenia and 1243 healthy controls). We found nominal evidence for association of alleles, rs926328 (χ2 = 4.44, p = 0.035, odds ratio = 1.13) and rs2235316 (χ2 = 4.41, p = 0.036, odds ratio = 1.13), with schizophrenia. However, these associations were no longer positive after correction for multiple testing (rs926328: corrected p = 0.105, rs2235316: corrected p = 0.108). We conclude that BIK might not play a major role in the susceptibility of schizophrenia in Japanese population.",
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Ohi, K, Hashimoto, R, Yasuda, Y, Yamamori, H, Hori, H, Saitoh, O, Tatsumi, M, Takeda, M, Iwata, N, Ozaki, N, Kamijima, K & Kunugi, H 2009, 'No association between the Bcl2-interacting killer (BIK) gene and schizophrenia', Neuroscience Letters, vol. 463, no. 1, pp. 60-63. https://doi.org/10.1016/j.neulet.2009.07.063

No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. / Ohi, Kazutaka; Hashimoto, Ryota; Yasuda, Yuka; Yamamori, Hidenaga; Hori, Hiroaki; Saitoh, Osamu; Tatsumi, Masahiko; Takeda, Masatoshi; Iwata, Nakao; Ozaki, Norio; Kamijima, Kunitoshi; Kunugi, Hiroshi.

In: Neuroscience Letters, Vol. 463, No. 1, 29.09.2009, p. 60-63.

Research output: Contribution to journalArticle

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AU - Ohi, Kazutaka

AU - Hashimoto, Ryota

AU - Yasuda, Yuka

AU - Yamamori, Hidenaga

AU - Hori, Hiroaki

AU - Saitoh, Osamu

AU - Tatsumi, Masahiko

AU - Takeda, Masatoshi

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Kamijima, Kunitoshi

AU - Kunugi, Hiroshi

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N2 - The Bcl2-interacting killer (BIK) gene interacts with cellular and viral survival-promoting proteins, such as Bcl-2, to enhance apoptosis. The BIK protein promotes cell death in a manner analogous to Bcl-2-related death-promoting proteins, Bax and Bak. There have been lower Bcl-2 levels and increased Bax/Bcl-2 ratio in the temporal cortex of patients with schizophrenia compared with those in controls. Because the death-promoting activity of BIK was suppressed in the presence of the cellular and viral survival-promoting proteins, the BIK protein is suggested as a likely target for antiapoptotic proteins. The purpose of this study is to investigate the association between genetic variants in the BIK gene and schizophrenia in a large Japanese population (1181 patients with schizophrenia and 1243 healthy controls). We found nominal evidence for association of alleles, rs926328 (χ2 = 4.44, p = 0.035, odds ratio = 1.13) and rs2235316 (χ2 = 4.41, p = 0.036, odds ratio = 1.13), with schizophrenia. However, these associations were no longer positive after correction for multiple testing (rs926328: corrected p = 0.105, rs2235316: corrected p = 0.108). We conclude that BIK might not play a major role in the susceptibility of schizophrenia in Japanese population.

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Ohi K, Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O et al. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neuroscience Letters. 2009 Sep 29;463(1):60-63. https://doi.org/10.1016/j.neulet.2009.07.063