No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population

Masashi Ikeda, Norio Ozaki, Yoshio Yamanouchi, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoko Kinoshita, Toshiya Inada, Nakao Iwata

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Abstract

Postmortem studies regarding schizophrenia revealed altered expression of genes related to γ-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD67). Moreover, several studies reported positive associations between the GAD67 gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalSchizophrenia Research
Volume91
Issue number1-3
DOIs
Publication statusPublished - 01-03-2007

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Glutamate Decarboxylase
Schizophrenia
Population
Genes
Butyric Acid
Synaptic Transmission
Sample Size
Single Nucleotide Polymorphism
Protein Isoforms
Gene Expression

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Ikeda, Masashi ; Ozaki, Norio ; Yamanouchi, Yoshio ; Suzuki, Tatsuyo ; Kitajima, Tsuyoshi ; Kinoshita, Yoko ; Inada, Toshiya ; Iwata, Nakao. / No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. In: Schizophrenia Research. 2007 ; Vol. 91, No. 1-3. pp. 22-26.
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No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population. / Ikeda, Masashi; Ozaki, Norio; Yamanouchi, Yoshio; Suzuki, Tatsuyo; Kitajima, Tsuyoshi; Kinoshita, Yoko; Inada, Toshiya; Iwata, Nakao.

In: Schizophrenia Research, Vol. 91, No. 1-3, 01.03.2007, p. 22-26.

Research output: Contribution to journalArticle

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