TY - JOUR
T1 - No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population
AU - Ikeda, Masashi
AU - Ozaki, Norio
AU - Yamanouchi, Yoshio
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Kinoshita, Yoko
AU - Inada, Toshiya
AU - Iwata, Nakao
N1 - Funding Information:
We thank Dr. Branko Aleksic for helpful discussion; and Ms S Nakaguchi and Ms M Miyata for their technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, and the Japan Health Sciences Foundation (Research on Health Sciences Focusing on Drug Innovation).
PY - 2007/3
Y1 - 2007/3
N2 - Postmortem studies regarding schizophrenia revealed altered expression of genes related to γ-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD67). Moreover, several studies reported positive associations between the GAD67 gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.
AB - Postmortem studies regarding schizophrenia revealed altered expression of genes related to γ-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD67). Moreover, several studies reported positive associations between the GAD67 gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.
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U2 - 10.1016/j.schres.2006.12.020
DO - 10.1016/j.schres.2006.12.020
M3 - Article
C2 - 17303389
AN - SCOPUS:33847302424
SN - 0920-9964
VL - 91
SP - 22
EP - 26
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
