TY - JOUR
T1 - No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population
AU - Aleksic, Branko
AU - Ikeda, Masashi
AU - Ishihara, Ryoko
AU - Saito, Shinichi
AU - Inada, Toshiya
AU - Iwata, Nakao
AU - Ozaki, Norio
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/9
Y1 - 2008/9
N2 - PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.
AB - PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.
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U2 - 10.1007/s10038-008-0318-7
DO - 10.1007/s10038-008-0318-7
M3 - Article
C2 - 18604471
AN - SCOPUS:50249117617
SN - 1434-5161
VL - 53
SP - 863
EP - 866
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 9
ER -