No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Branko Aleksic, Masashi Ikeda, Ryoko Ishihara, Shinichi Saito, Toshiya Inada, Nakao Iwata, Norio Ozaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.

Original languageEnglish
Pages (from-to)863-866
Number of pages4
JournalJournal of Human Genetics
Volume53
Issue number9
DOIs
Publication statusPublished - 09-2008

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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