No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Branko Aleksic; Masashi Ikeda; Ryoko Ishihara; Shinichi Saito; Toshiya Inada; Nakao Iwata; Norio Ozaki

doi:10.1007/s10038-008-0318-7

No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Branko Aleksic
, Masashi Ikeda
, Ryoko Ishihara
, Shinichi Saito
, Toshiya Inada
, Nakao Iwata
, Norio Ozaki

visiting faculty

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.

Original language	English
Pages (from-to)	863-866
Number of pages	4
Journal	Journal of Human Genetics
Volume	53
Issue number	9
DOIs	https://doi.org/10.1007/s10038-008-0318-7
Publication status	Published - 09-2008

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1007/s10038-008-0318-7

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abstract = "PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.",

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AU - Aleksic, Branko

AU - Ikeda, Masashi

AU - Ishihara, Ryoko

AU - Saito, Shinichi

AU - Inada, Toshiya

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2008/9

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AB - PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.

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JO - Journal of Human Genetics

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No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Abstract

All Science Journal Classification (ASJC) codes

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